Detectability of cerebellar activity with magnetoencephalography and electroencephalography
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Electrophysiological signals from the cerebellum have traditionally been viewed as inaccessible to magnetoencephalography (MEG) and electroencephalography (EEG). Here, we challenge this position by investigating the ability...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022
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| Online Access: | https://hdl.handle.net/1721.1/141258 |
| _version_ | 1826210259607224320 |
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| author | Samuelsson, JG Sundaram, P Khan, S Sereno, MI Hämäläinen, MS |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Samuelsson, JG Sundaram, P Khan, S Sereno, MI Hämäläinen, MS |
| author_sort | Samuelsson, JG |
| collection | MIT |
| description | © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Electrophysiological signals from the cerebellum have traditionally been viewed as inaccessible to magnetoencephalography (MEG) and electroencephalography (EEG). Here, we challenge this position by investigating the ability of MEG and EEG to detect cerebellar activity using a model that employs a high-resolution tessellation of the cerebellar cortex. The tessellation was constructed from repetitive high-field (9.4T) structural magnetic resonance imaging (MRI) of an ex vivo human cerebellum. A boundary-element forward model was then used to simulate the M/EEG signals resulting from neural activity in the cerebellar cortex. Despite significant signal cancelation due to the highly convoluted cerebellar cortex, we found that the cerebellar signal was on average only 30–60% weaker than the cortical signal. We also made detailed M/EEG sensitivity maps and found that MEG and EEG have highly complementary sensitivity distributions over the cerebellar cortex. Based on previous fMRI studies combined with our M/EEG sensitivity maps, we discuss experimental paradigms that are likely to offer high M/EEG sensitivity to cerebellar activity. Taken together, these results show that cerebellar activity should be clearly detectable by current M/EEG systems with an appropriate experimental setup. |
| first_indexed | 2024-09-23T14:46:39Z |
| format | Article |
| id | mit-1721.1/141258 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:46:39Z |
| publishDate | 2022 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1412582023-04-13T15:55:14Z Detectability of cerebellar activity with magnetoencephalography and electroencephalography Samuelsson, JG Sundaram, P Khan, S Sereno, MI Hämäläinen, MS Harvard University--MIT Division of Health Sciences and Technology © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Electrophysiological signals from the cerebellum have traditionally been viewed as inaccessible to magnetoencephalography (MEG) and electroencephalography (EEG). Here, we challenge this position by investigating the ability of MEG and EEG to detect cerebellar activity using a model that employs a high-resolution tessellation of the cerebellar cortex. The tessellation was constructed from repetitive high-field (9.4T) structural magnetic resonance imaging (MRI) of an ex vivo human cerebellum. A boundary-element forward model was then used to simulate the M/EEG signals resulting from neural activity in the cerebellar cortex. Despite significant signal cancelation due to the highly convoluted cerebellar cortex, we found that the cerebellar signal was on average only 30–60% weaker than the cortical signal. We also made detailed M/EEG sensitivity maps and found that MEG and EEG have highly complementary sensitivity distributions over the cerebellar cortex. Based on previous fMRI studies combined with our M/EEG sensitivity maps, we discuss experimental paradigms that are likely to offer high M/EEG sensitivity to cerebellar activity. Taken together, these results show that cerebellar activity should be clearly detectable by current M/EEG systems with an appropriate experimental setup. 2022-03-17T15:38:51Z 2022-03-17T15:38:51Z 2020-06-15 2022-03-17T15:08:39Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/141258 Samuelsson, JG, Sundaram, P, Khan, S, Sereno, MI and Hämäläinen, MS. 2020. "Detectability of cerebellar activity with magnetoencephalography and electroencephalography." Human Brain Mapping, 41 (9). en 10.1002/hbm.24951 Human Brain Mapping Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Samuelsson, JG Sundaram, P Khan, S Sereno, MI Hämäläinen, MS Detectability of cerebellar activity with magnetoencephalography and electroencephalography |
| title | Detectability of cerebellar activity with magnetoencephalography and electroencephalography |
| title_full | Detectability of cerebellar activity with magnetoencephalography and electroencephalography |
| title_fullStr | Detectability of cerebellar activity with magnetoencephalography and electroencephalography |
| title_full_unstemmed | Detectability of cerebellar activity with magnetoencephalography and electroencephalography |
| title_short | Detectability of cerebellar activity with magnetoencephalography and electroencephalography |
| title_sort | detectability of cerebellar activity with magnetoencephalography and electroencephalography |
| url | https://hdl.handle.net/1721.1/141258 |
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