Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity
© 2020 The Author(s) Inflammasome activation in dendritic cells (DCs) leads to pyroptosis or hyperactivation. Zhivaki et al. show that in contrast to pyroptotic DCs, hyperactive DCs stimulate durable anti-tumor immunity that eradicates established tumors. These protective responses are intrinsic to...
| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elsevier BV
2022
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| Online Access: | https://hdl.handle.net/1721.1/141288 |
| _version_ | 1826204501275574272 |
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| author | Zhivaki, Dania Borriello, Francesco Chow, Ohn A Doran, Benjamin Fleming, Ira Theisen, Derek J Pallis, Paris Shalek, Alex K Sokol, Caroline L Zanoni, Ivan Kagan, Jonathan C |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Zhivaki, Dania Borriello, Francesco Chow, Ohn A Doran, Benjamin Fleming, Ira Theisen, Derek J Pallis, Paris Shalek, Alex K Sokol, Caroline L Zanoni, Ivan Kagan, Jonathan C |
| author_sort | Zhivaki, Dania |
| collection | MIT |
| description | © 2020 The Author(s) Inflammasome activation in dendritic cells (DCs) leads to pyroptosis or hyperactivation. Zhivaki et al. show that in contrast to pyroptotic DCs, hyperactive DCs stimulate durable anti-tumor immunity that eradicates established tumors. These protective responses are intrinsic to cDC1 cells and depend on DC hypermigration and on the inflammasome-dependent cytokine IL-1β. |
| first_indexed | 2024-09-23T12:56:37Z |
| format | Article |
| id | mit-1721.1/141288 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:56:37Z |
| publishDate | 2022 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1412882024-03-20T18:57:54Z Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity Zhivaki, Dania Borriello, Francesco Chow, Ohn A Doran, Benjamin Fleming, Ira Theisen, Derek J Pallis, Paris Shalek, Alex K Sokol, Caroline L Zanoni, Ivan Kagan, Jonathan C Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Institute for Medical Engineering & Science Koch Institute for Integrative Cancer Research at MIT Ragon Institute of MGH, MIT and Harvard © 2020 The Author(s) Inflammasome activation in dendritic cells (DCs) leads to pyroptosis or hyperactivation. Zhivaki et al. show that in contrast to pyroptotic DCs, hyperactive DCs stimulate durable anti-tumor immunity that eradicates established tumors. These protective responses are intrinsic to cDC1 cells and depend on DC hypermigration and on the inflammasome-dependent cytokine IL-1β. 2022-03-18T14:51:01Z 2022-03-18T14:51:01Z 2020 2022-03-18T14:34:54Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/141288 Zhivaki, Dania, Borriello, Francesco, Chow, Ohn A, Doran, Benjamin, Fleming, Ira et al. 2020. "Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity." Cell Reports, 33 (7). en 10.1016/J.CELREP.2020.108381 Cell Reports Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Zhivaki, Dania Borriello, Francesco Chow, Ohn A Doran, Benjamin Fleming, Ira Theisen, Derek J Pallis, Paris Shalek, Alex K Sokol, Caroline L Zanoni, Ivan Kagan, Jonathan C Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity |
| title | Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity |
| title_full | Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity |
| title_fullStr | Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity |
| title_full_unstemmed | Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity |
| title_short | Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity |
| title_sort | inflammasomes within hyperactive murine dendritic cells stimulate long lived t cell mediated anti tumor immunity |
| url | https://hdl.handle.net/1721.1/141288 |
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