Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea
Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections has proven particularly challenging, with most reported treatment failures of the first-line drug ceftriaxone occurring at t...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Oxford University Press (OUP)
2022
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| Online Access: | https://hdl.handle.net/1721.1/141390 |
| _version_ | 1811094595831857152 |
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| author | Palace, Samantha G Fryling, Kyra E Li, Ying Wentworth, Adam J Traverso, Giovanni Grad, Yonatan H |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Palace, Samantha G Fryling, Kyra E Li, Ying Wentworth, Adam J Traverso, Giovanni Grad, Yonatan H |
| author_sort | Palace, Samantha G |
| collection | MIT |
| description | Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections has proven particularly challenging, with most reported treatment failures of the first-line drug ceftriaxone occurring at this site and lower cure rates in recent trials of new antibiotics reported for oropharyngeal infections compared with other sites of infection. However, the accessibility of the oropharynx to topical therapeutics provides an opportunity for intervention. Local delivery of a therapeutic at a high concentration would enable the use of non-traditional antimicrobial candidates, including biological molecules that exploit underlying chemical sensitivities of N. gonorrhoeae but lack the potency or pharmacokinetic profiles required for effective systemic administration. |
| first_indexed | 2024-09-23T16:02:30Z |
| format | Article |
| id | mit-1721.1/141390 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:02:30Z |
| publishDate | 2022 |
| publisher | Oxford University Press (OUP) |
| record_format | dspace |
| spelling | mit-1721.1/1413902023-02-14T20:04:46Z Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea Palace, Samantha G Fryling, Kyra E Li, Ying Wentworth, Adam J Traverso, Giovanni Grad, Yonatan H Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Mechanical Engineering Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections has proven particularly challenging, with most reported treatment failures of the first-line drug ceftriaxone occurring at this site and lower cure rates in recent trials of new antibiotics reported for oropharyngeal infections compared with other sites of infection. However, the accessibility of the oropharynx to topical therapeutics provides an opportunity for intervention. Local delivery of a therapeutic at a high concentration would enable the use of non-traditional antimicrobial candidates, including biological molecules that exploit underlying chemical sensitivities of N. gonorrhoeae but lack the potency or pharmacokinetic profiles required for effective systemic administration. 2022-03-29T18:33:17Z 2022-03-29T18:33:17Z 2021 2022-03-29T18:23:42Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/141390 Palace, Samantha G, Fryling, Kyra E, Li, Ying, Wentworth, Adam J, Traverso, Giovanni et al. 2021. "Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea." Journal of Antimicrobial Chemotherapy, 76 (10). en 10.1093/JAC/DKAB217 Journal of Antimicrobial Chemotherapy Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf application/pdf Oxford University Press (OUP) Prof. Traverso via Elizabeth Kuhlman |
| spellingShingle | Palace, Samantha G Fryling, Kyra E Li, Ying Wentworth, Adam J Traverso, Giovanni Grad, Yonatan H Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea |
| title | Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea |
| title_full | Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea |
| title_fullStr | Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea |
| title_full_unstemmed | Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea |
| title_short | Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea |
| title_sort | identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea |
| url | https://hdl.handle.net/1721.1/141390 |
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