Kirigami-inspired stents for sustained local delivery of therapeutics
Implantable drug depots have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential systemic side effects. Tubular organs including the gastrointestinal tract, respiratory tract and vasculature all manifest with endoluminal disease. The anato...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2022
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| Online Access: | https://hdl.handle.net/1721.1/141398 |
| _version_ | 1811069214389174272 |
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| author | Babaee, Sahab Shi, Yichao Abbasalizadeh, Saeed Tamang, Siddartha Hess, Kaitlyn Collins, Joy E Ishida, Keiko Lopes, Aaron Williams, Michael Albaghdadi, Mazen Hayward, Alison M Traverso, Giovanni |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Babaee, Sahab Shi, Yichao Abbasalizadeh, Saeed Tamang, Siddartha Hess, Kaitlyn Collins, Joy E Ishida, Keiko Lopes, Aaron Williams, Michael Albaghdadi, Mazen Hayward, Alison M Traverso, Giovanni |
| author_sort | Babaee, Sahab |
| collection | MIT |
| description | Implantable drug depots have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential systemic side effects. Tubular organs including the gastrointestinal tract, respiratory tract and vasculature all manifest with endoluminal disease. The anatomic distribution of localized drug delivery for these organs using existing therapeutic modalities is limited. Application of local depots in a circumferential and extended longitudinal fashion could transform our capacity to offer effective treatment across a range of conditions. Here we report the development and application of a kirigami-based stent platform to achieve this. The stents comprise a stretchable snake-skin-inspired kirigami shell integrated with a fluidically driven linear soft actuator. They have the capacity to deposit drug depots circumferentially and longitudinally in the tubular mucosa of the gastrointestinal tract across millimetre to multi-centimetre length scales, as well as in the vasculature and large airways. We characterize the mechanics of kirigami stents for injection, and their capacity to engage tissue in a controlled manner and deposit degradable microparticles loaded with therapeutics by evaluating these systems ex vivo and in vivo in swine. We anticipate such systems could be applied for a range of endoluminal diseases by simplifying dosing regimens while maximizing drug on-target effects through the sustained release of therapeutics and minimizing systemic side effects. |
| first_indexed | 2024-09-23T08:07:32Z |
| format | Article |
| id | mit-1721.1/141398 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:07:32Z |
| publishDate | 2022 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1413982023-03-29T19:52:23Z Kirigami-inspired stents for sustained local delivery of therapeutics Babaee, Sahab Shi, Yichao Abbasalizadeh, Saeed Tamang, Siddartha Hess, Kaitlyn Collins, Joy E Ishida, Keiko Lopes, Aaron Williams, Michael Albaghdadi, Mazen Hayward, Alison M Traverso, Giovanni Massachusetts Institute of Technology. Department of Mechanical Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Implantable drug depots have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential systemic side effects. Tubular organs including the gastrointestinal tract, respiratory tract and vasculature all manifest with endoluminal disease. The anatomic distribution of localized drug delivery for these organs using existing therapeutic modalities is limited. Application of local depots in a circumferential and extended longitudinal fashion could transform our capacity to offer effective treatment across a range of conditions. Here we report the development and application of a kirigami-based stent platform to achieve this. The stents comprise a stretchable snake-skin-inspired kirigami shell integrated with a fluidically driven linear soft actuator. They have the capacity to deposit drug depots circumferentially and longitudinally in the tubular mucosa of the gastrointestinal tract across millimetre to multi-centimetre length scales, as well as in the vasculature and large airways. We characterize the mechanics of kirigami stents for injection, and their capacity to engage tissue in a controlled manner and deposit degradable microparticles loaded with therapeutics by evaluating these systems ex vivo and in vivo in swine. We anticipate such systems could be applied for a range of endoluminal diseases by simplifying dosing regimens while maximizing drug on-target effects through the sustained release of therapeutics and minimizing systemic side effects. 2022-03-30T13:21:30Z 2022-03-30T13:21:30Z 2021 2022-03-30T13:10:08Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/141398 Babaee, Sahab, Shi, Yichao, Abbasalizadeh, Saeed, Tamang, Siddartha, Hess, Kaitlyn et al. 2021. "Kirigami-inspired stents for sustained local delivery of therapeutics." Nature Materials, 20 (8). en 10.1038/S41563-021-01031-1 Nature Materials Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer Science and Business Media LLC Prof. Traverso via Elizabeth Kuhlman |
| spellingShingle | Babaee, Sahab Shi, Yichao Abbasalizadeh, Saeed Tamang, Siddartha Hess, Kaitlyn Collins, Joy E Ishida, Keiko Lopes, Aaron Williams, Michael Albaghdadi, Mazen Hayward, Alison M Traverso, Giovanni Kirigami-inspired stents for sustained local delivery of therapeutics |
| title | Kirigami-inspired stents for sustained local delivery of therapeutics |
| title_full | Kirigami-inspired stents for sustained local delivery of therapeutics |
| title_fullStr | Kirigami-inspired stents for sustained local delivery of therapeutics |
| title_full_unstemmed | Kirigami-inspired stents for sustained local delivery of therapeutics |
| title_short | Kirigami-inspired stents for sustained local delivery of therapeutics |
| title_sort | kirigami inspired stents for sustained local delivery of therapeutics |
| url | https://hdl.handle.net/1721.1/141398 |
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