Topological braiding and virtual particles on the cell membrane
<jats:title>Significance</jats:title> <jats:p>Topological defects are robust particle-like structures that essentially determine the mechanics and dynamics of physical and biological matter. Examples range from vortices in quantum superfluids to the cores of spiral wave...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Proceedings of the National Academy of Sciences
2022
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| Online Access: | https://hdl.handle.net/1721.1/141728 |
| _version_ | 1811089872986832896 |
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| author | Liu, Jinghui Totz, Jan F Miller, Pearson W Hastewell, Alasdair D Chao, Yu-Chen Dunkel, Jörn Fakhri, Nikta |
| author2 | Massachusetts Institute of Technology. Department of Physics |
| author_facet | Massachusetts Institute of Technology. Department of Physics Liu, Jinghui Totz, Jan F Miller, Pearson W Hastewell, Alasdair D Chao, Yu-Chen Dunkel, Jörn Fakhri, Nikta |
| author_sort | Liu, Jinghui |
| collection | MIT |
| description | <jats:title>Significance</jats:title>
<jats:p>Topological defects are robust particle-like structures that essentially determine the mechanics and dynamics of physical and biological matter. Examples range from vortices in quantum superfluids to the cores of spiral wave patterns in the brain. In biological systems, such defects play important roles as organizers of biochemical signaling patterns, cellular forces, and even cell death. Combining direct experimental observations with mathematical modeling and chemical perturbations, we investigated the dynamics of spiral wave defects on the surfaces of starfish egg cells. Our quantitative analysis showed that these defects exhibit complex braiding, pair creation, and annihilation dynamics, in agreement with predictions from a generic continuum theory. More broadly, these results suggest interesting parallels between information transport in living and quantum systems.</jats:p> |
| first_indexed | 2024-09-23T14:26:09Z |
| format | Article |
| id | mit-1721.1/141728 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:26:09Z |
| publishDate | 2022 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1417282023-02-10T20:59:30Z Topological braiding and virtual particles on the cell membrane Liu, Jinghui Totz, Jan F Miller, Pearson W Hastewell, Alasdair D Chao, Yu-Chen Dunkel, Jörn Fakhri, Nikta Massachusetts Institute of Technology. Department of Physics Massachusetts Institute of Technology. Department of Mathematics Massachusetts Institute of Technology. Department of Mechanical Engineering <jats:title>Significance</jats:title> <jats:p>Topological defects are robust particle-like structures that essentially determine the mechanics and dynamics of physical and biological matter. Examples range from vortices in quantum superfluids to the cores of spiral wave patterns in the brain. In biological systems, such defects play important roles as organizers of biochemical signaling patterns, cellular forces, and even cell death. Combining direct experimental observations with mathematical modeling and chemical perturbations, we investigated the dynamics of spiral wave defects on the surfaces of starfish egg cells. Our quantitative analysis showed that these defects exhibit complex braiding, pair creation, and annihilation dynamics, in agreement with predictions from a generic continuum theory. More broadly, these results suggest interesting parallels between information transport in living and quantum systems.</jats:p> 2022-04-07T12:19:49Z 2022-04-07T12:19:49Z 2021 2022-04-07T12:15:16Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/141728 Liu, Jinghui, Totz, Jan F, Miller, Pearson W, Hastewell, Alasdair D, Chao, Yu-Chen et al. 2021. "Topological braiding and virtual particles on the cell membrane." Proceedings of the National Academy of Sciences of the United States of America, 118 (34). en 10.1073/PNAS.2104191118 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Liu, Jinghui Totz, Jan F Miller, Pearson W Hastewell, Alasdair D Chao, Yu-Chen Dunkel, Jörn Fakhri, Nikta Topological braiding and virtual particles on the cell membrane |
| title | Topological braiding and virtual particles on the cell membrane |
| title_full | Topological braiding and virtual particles on the cell membrane |
| title_fullStr | Topological braiding and virtual particles on the cell membrane |
| title_full_unstemmed | Topological braiding and virtual particles on the cell membrane |
| title_short | Topological braiding and virtual particles on the cell membrane |
| title_sort | topological braiding and virtual particles on the cell membrane |
| url | https://hdl.handle.net/1721.1/141728 |
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