Slow expanders invade by forming dented fronts in microbial colonies
Significance Living organisms never cease to evolve, so there is a significant interest in predicting and controlling evolution in all branches of life sciences. The most basic question is whether a trait should increase or decrease in a given environment. The answer seems to be trivial for traits...
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| Format: | Article |
| Language: | English |
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Proceedings of the National Academy of Sciences
2022
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| Online Access: | https://hdl.handle.net/1721.1/141895 |
| _version_ | 1826213487721840640 |
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| author | Lee, Hyunseok Gore, Jeff Korolev, Kirill S |
| author2 | Massachusetts Institute of Technology. Department of Physics |
| author_facet | Massachusetts Institute of Technology. Department of Physics Lee, Hyunseok Gore, Jeff Korolev, Kirill S |
| author_sort | Lee, Hyunseok |
| collection | MIT |
| description | Significance
Living organisms never cease to evolve, so there is a significant interest in predicting and controlling evolution in all branches of life sciences. The most basic question is whether a trait should increase or decrease in a given environment. The answer seems to be trivial for traits such as the growth rate in a bioreactor or the expansion rate of a tumor. Yet, it has been suggested that such traits can decrease, rather than increase, during evolution. Here, we report a mutant that outcompeted the ancestor despite having a slower expansion velocity when in isolation. To explain this observation, we developed and validated a theory that describes spatial competition between organisms with different expansion rates and arbitrary competitive interactions. |
| first_indexed | 2024-09-23T15:49:59Z |
| format | Article |
| id | mit-1721.1/141895 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:49:59Z |
| publishDate | 2022 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1418952023-01-27T21:49:53Z Slow expanders invade by forming dented fronts in microbial colonies Lee, Hyunseok Gore, Jeff Korolev, Kirill S Massachusetts Institute of Technology. Department of Physics Significance Living organisms never cease to evolve, so there is a significant interest in predicting and controlling evolution in all branches of life sciences. The most basic question is whether a trait should increase or decrease in a given environment. The answer seems to be trivial for traits such as the growth rate in a bioreactor or the expansion rate of a tumor. Yet, it has been suggested that such traits can decrease, rather than increase, during evolution. Here, we report a mutant that outcompeted the ancestor despite having a slower expansion velocity when in isolation. To explain this observation, we developed and validated a theory that describes spatial competition between organisms with different expansion rates and arbitrary competitive interactions. 2022-04-13T17:32:53Z 2022-04-13T17:32:53Z 2022-01-05 2022-04-13T17:29:31Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/141895 Lee, Hyunseok, Gore, Jeff and Korolev, Kirill S. 2022. "Slow expanders invade by forming dented fronts in microbial colonies." Proceedings of the National Academy of Sciences, 119 (1). en 10.1073/pnas.2108653119 Proceedings of the National Academy of Sciences Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Lee, Hyunseok Gore, Jeff Korolev, Kirill S Slow expanders invade by forming dented fronts in microbial colonies |
| title | Slow expanders invade by forming dented fronts in microbial colonies |
| title_full | Slow expanders invade by forming dented fronts in microbial colonies |
| title_fullStr | Slow expanders invade by forming dented fronts in microbial colonies |
| title_full_unstemmed | Slow expanders invade by forming dented fronts in microbial colonies |
| title_short | Slow expanders invade by forming dented fronts in microbial colonies |
| title_sort | slow expanders invade by forming dented fronts in microbial colonies |
| url | https://hdl.handle.net/1721.1/141895 |
| work_keys_str_mv | AT leehyunseok slowexpandersinvadebyformingdentedfrontsinmicrobialcolonies AT gorejeff slowexpandersinvadebyformingdentedfrontsinmicrobialcolonies AT korolevkirills slowexpandersinvadebyformingdentedfrontsinmicrobialcolonies |