Changes in Brain Neuroimmunology Following Injury and Disease
<jats:p>The nervous and immune systems are intimately related in the brain and in the periphery, where changes to one affect the other and vice-versa. Immune cells are responsible for sculpting and pruning neuronal synapses, and play key roles in neuro-development and neurological disease path...
| Principais autores: | , , , |
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| Formato: | Artigo |
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Frontiers Media SA
2022
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| Acesso em linha: | https://hdl.handle.net/1721.1/142239 |
| _version_ | 1826196350362976256 |
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| author | Tabet, Anthony Apra, Caroline Stranahan, Alexis M. Anikeeva, Polina |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Tabet, Anthony Apra, Caroline Stranahan, Alexis M. Anikeeva, Polina |
| author_sort | Tabet, Anthony |
| collection | MIT |
| description | <jats:p>The nervous and immune systems are intimately related in the brain and in the periphery, where changes to one affect the other and vice-versa. Immune cells are responsible for sculpting and pruning neuronal synapses, and play key roles in neuro-development and neurological disease pathology. The immune composition of the brain is tightly regulated from the periphery through the blood-brain barrier (BBB), whose maintenance is driven to a significant extent by extracellular matrix (ECM) components. After a brain insult, the BBB can become disrupted and the composition of the ECM can change. These changes, and the resulting immune infiltration, can have detrimental effects on neurophysiology and are the hallmarks of several diseases. In this review, we discuss some processes that may occur after insult, and potential consequences to brain neuroimmunology and disease progression. We then highlight future research directions and opportunities for further tool development to probe the neuro-immune interface.</jats:p> |
| first_indexed | 2024-09-23T10:25:31Z |
| format | Article |
| id | mit-1721.1/142239 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:25:31Z |
| publishDate | 2022 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | mit-1721.1/1422392023-02-09T19:25:47Z Changes in Brain Neuroimmunology Following Injury and Disease Tabet, Anthony Apra, Caroline Stranahan, Alexis M. Anikeeva, Polina McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Research Laboratory of Electronics Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences <jats:p>The nervous and immune systems are intimately related in the brain and in the periphery, where changes to one affect the other and vice-versa. Immune cells are responsible for sculpting and pruning neuronal synapses, and play key roles in neuro-development and neurological disease pathology. The immune composition of the brain is tightly regulated from the periphery through the blood-brain barrier (BBB), whose maintenance is driven to a significant extent by extracellular matrix (ECM) components. After a brain insult, the BBB can become disrupted and the composition of the ECM can change. These changes, and the resulting immune infiltration, can have detrimental effects on neurophysiology and are the hallmarks of several diseases. In this review, we discuss some processes that may occur after insult, and potential consequences to brain neuroimmunology and disease progression. We then highlight future research directions and opportunities for further tool development to probe the neuro-immune interface.</jats:p> 2022-05-03T12:32:39Z 2022-05-03T12:32:39Z 2022-04-27 Article http://purl.org/eprint/type/JournalArticle 1662-5145 https://hdl.handle.net/1721.1/142239 Tabet, Anthony, Apra, Caroline, Stranahan, Alexis M. and Anikeeva, Polina. 2022. "Changes in Brain Neuroimmunology Following Injury and Disease." 16. 10.3389/fnint.2022.894500 Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0 application/pdf Frontiers Media SA Frontiers |
| spellingShingle | Tabet, Anthony Apra, Caroline Stranahan, Alexis M. Anikeeva, Polina Changes in Brain Neuroimmunology Following Injury and Disease |
| title | Changes in Brain Neuroimmunology Following Injury and Disease |
| title_full | Changes in Brain Neuroimmunology Following Injury and Disease |
| title_fullStr | Changes in Brain Neuroimmunology Following Injury and Disease |
| title_full_unstemmed | Changes in Brain Neuroimmunology Following Injury and Disease |
| title_short | Changes in Brain Neuroimmunology Following Injury and Disease |
| title_sort | changes in brain neuroimmunology following injury and disease |
| url | https://hdl.handle.net/1721.1/142239 |
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