Remotely Controlled Proton Generation for Neuromodulation
Copyright © 2020 American Chemical Society. Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting noninvasive alternating magnetic fields (AMFs) into pro...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS)
2022
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| Online Access: | https://hdl.handle.net/1721.1/142480 |
| _version_ | 1826189094315622400 |
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| author | Park, Jimin Tabet, Anthony Moon, Junsang Chiang, Po-Han Koehler, Florian Sahasrabudhe, Atharva Anikeeva, Polina |
| author2 | Massachusetts Institute of Technology. Department of Materials Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Materials Science and Engineering Park, Jimin Tabet, Anthony Moon, Junsang Chiang, Po-Han Koehler, Florian Sahasrabudhe, Atharva Anikeeva, Polina |
| author_sort | Park, Jimin |
| collection | MIT |
| description | Copyright © 2020 American Chemical Society. Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting noninvasive alternating magnetic fields (AMFs) into protons in physiological environments by combining magnetic nanoparticles (MNPs) with polymeric scaffolds. When exposed to AMFs, the heat dissipated by MNPs triggered a hydrolytic degradation of surrounding polyanhydride or polyester, releasing protons into the extracellular space. pH changes induced by these nanotransducers can be tuned by changing the polymer chemistry or AMF stimulation parameters. Remote magnetic control of local protons was shown to trigger acid-sensing ion channels and to evoke intracellular calcium influx in neurons. By offering a wireless modulation of local pH, our approach can accelerate the mechanistic investigation of the role of protons in biochemical signaling in the nervous system. |
| first_indexed | 2024-09-23T08:09:46Z |
| format | Article |
| id | mit-1721.1/142480 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:09:46Z |
| publishDate | 2022 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1424802023-02-09T17:51:56Z Remotely Controlled Proton Generation for Neuromodulation Park, Jimin Tabet, Anthony Moon, Junsang Chiang, Po-Han Koehler, Florian Sahasrabudhe, Atharva Anikeeva, Polina Massachusetts Institute of Technology. Department of Materials Science and Engineering Massachusetts Institute of Technology. Research Laboratory of Electronics McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Copyright © 2020 American Chemical Society. Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting noninvasive alternating magnetic fields (AMFs) into protons in physiological environments by combining magnetic nanoparticles (MNPs) with polymeric scaffolds. When exposed to AMFs, the heat dissipated by MNPs triggered a hydrolytic degradation of surrounding polyanhydride or polyester, releasing protons into the extracellular space. pH changes induced by these nanotransducers can be tuned by changing the polymer chemistry or AMF stimulation parameters. Remote magnetic control of local protons was shown to trigger acid-sensing ion channels and to evoke intracellular calcium influx in neurons. By offering a wireless modulation of local pH, our approach can accelerate the mechanistic investigation of the role of protons in biochemical signaling in the nervous system. 2022-05-11T16:47:12Z 2022-05-11T16:47:12Z 2020 2022-05-11T16:43:56Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/142480 Park, Jimin, Tabet, Anthony, Moon, Junsang, Chiang, Po-Han, Koehler, Florian et al. 2020. "Remotely Controlled Proton Generation for Neuromodulation." Nano Letters, 20 (9). en 10.1021/ACS.NANOLETT.0C02281 Nano Letters Attribution-NonCommercial-ShareAlike 4.0 International https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Park, Jimin Tabet, Anthony Moon, Junsang Chiang, Po-Han Koehler, Florian Sahasrabudhe, Atharva Anikeeva, Polina Remotely Controlled Proton Generation for Neuromodulation |
| title | Remotely Controlled Proton Generation for Neuromodulation |
| title_full | Remotely Controlled Proton Generation for Neuromodulation |
| title_fullStr | Remotely Controlled Proton Generation for Neuromodulation |
| title_full_unstemmed | Remotely Controlled Proton Generation for Neuromodulation |
| title_short | Remotely Controlled Proton Generation for Neuromodulation |
| title_sort | remotely controlled proton generation for neuromodulation |
| url | https://hdl.handle.net/1721.1/142480 |
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