A Robust Method for Perfusable Microvascular Network Formation In Vitro

Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key chara...

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書目詳細資料
Main Authors: Wan, Zhengpeng, Zhong, Amy X, Zhang, Shun, Pavlou, Georgios, Coughlin, Mark F, Shelton, Sarah E, Nguyen, Huu Tuan, Lorch, Jochen H, Barbie, David A, Kamm, Roger D
其他作者: Massachusetts Institute of Technology. Department of Biological Engineering
格式: Article
語言:English
出版: Wiley 2022
在線閱讀:https://hdl.handle.net/1721.1/142858
實物特徵
總結:Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics of MVN formation is investigated and a robust two-step seeding strategy to generate perfusable physiological MVNs in microfluidic devices is established.