A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
Accurate chromosome segregation during cell division is critical to cellular fitness and survival. Errors during the segregation process often lead to aneuploidy, a state where cells harbor whole chromosome gains or losses. In untransformed cells, aneuploidy is highly detrimental to cell physiology,...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/143426 |