Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Malignant transformation and tumour progression are associated with cancer-cell softening. Yet how the biomechanics of cancer cells affects T-cell-mediated cytotoxicity and thus the outcomes of adoptive T-cell immunotherapies is unknown. Here we show that T-cell-mediated cancer-cell killing is hampe...

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Bibliographic Details
Main Authors: Lei, Kewen, Kurum, Armand, Kaynak, Murat, Bonati, Lucia, Han, Yulong, Cencen, Veronika, Gao, Min, Xie, Yu-Qing, Guo, Yugang, Hannebelle, Mélanie TM, Wu, Yangping, Zhou, Guanyu, Guo, Ming, Fantner, Georg E, Sakar, Mahmut Selman, Tang, Li
Other Authors: Massachusetts Institute of Technology. Department of Mechanical Engineering
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2022
Online Access:https://hdl.handle.net/1721.1/143449

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