Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits
The purpose of this study is to quantitatively assess correlations between local geographic atrophy (GA) growth rates and local optical coherence tomography angiography (OCTA)-measured choriocapillaris (CC) flow deficits. Thirty-eight eyes from 27 patients with GA secondary to age-related macular de...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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The Optical Society
2022
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| Online Access: | https://hdl.handle.net/1721.1/143546 |
| _version_ | 1826188952745279488 |
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| author | Moult, Eric M Shi, Yingying Zhang, Qinqin Wang, Liang Mazumder, Rahul Chen, Siyu Chu, Zhongdi Feuer, William Waheed, Nadia K Gregori, Giovanni Wang, Ruikang K Rosenfeld, Philip J Fujimoto, James G |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Moult, Eric M Shi, Yingying Zhang, Qinqin Wang, Liang Mazumder, Rahul Chen, Siyu Chu, Zhongdi Feuer, William Waheed, Nadia K Gregori, Giovanni Wang, Ruikang K Rosenfeld, Philip J Fujimoto, James G |
| author_sort | Moult, Eric M |
| collection | MIT |
| description | The purpose of this study is to quantitatively assess correlations between local geographic atrophy (GA) growth rates and local optical coherence tomography angiography (OCTA)-measured choriocapillaris (CC) flow deficits. Thirty-eight eyes from 27 patients with GA secondary to age-related macular degeneration (AMD) were imaged with a commercial 1050 nm swept-source OCTA instrument at 3 visits, each separated by ∼6 months. Pearson correlations were computed between local GA growth rates, estimated using a biophysical GA growth model, and local OCTA CC flow deficit percentages measured along the GA margins of the baseline visits. The p-values associated with the null hypothesis of no Pearson correlation were estimated using a Monte Carlo permutation scheme that incorporates the effects of spatial autocorrelation. The null hypothesis (Pearson's ρ = 0) was rejected at a Benjamini-Hochberg false discovery rate of 0.2 in 15 of the 114 visit pairs, 11 of which exhibited positive correlations; even amongst these 11 visit pairs, correlations were modest (r in [0.30, 0.53]). The presented framework appears well suited to evaluating other potential imaging biomarkers of local GA growth rates. |
| first_indexed | 2024-09-23T08:07:32Z |
| format | Article |
| id | mit-1721.1/143546 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:07:32Z |
| publishDate | 2022 |
| publisher | The Optical Society |
| record_format | dspace |
| spelling | mit-1721.1/1435462023-03-29T19:50:59Z Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits Moult, Eric M Shi, Yingying Zhang, Qinqin Wang, Liang Mazumder, Rahul Chen, Siyu Chu, Zhongdi Feuer, William Waheed, Nadia K Gregori, Giovanni Wang, Ruikang K Rosenfeld, Philip J Fujimoto, James G Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Harvard University--MIT Division of Health Sciences and Technology Sloan School of Management Massachusetts Institute of Technology. Operations Research Center The purpose of this study is to quantitatively assess correlations between local geographic atrophy (GA) growth rates and local optical coherence tomography angiography (OCTA)-measured choriocapillaris (CC) flow deficits. Thirty-eight eyes from 27 patients with GA secondary to age-related macular degeneration (AMD) were imaged with a commercial 1050 nm swept-source OCTA instrument at 3 visits, each separated by ∼6 months. Pearson correlations were computed between local GA growth rates, estimated using a biophysical GA growth model, and local OCTA CC flow deficit percentages measured along the GA margins of the baseline visits. The p-values associated with the null hypothesis of no Pearson correlation were estimated using a Monte Carlo permutation scheme that incorporates the effects of spatial autocorrelation. The null hypothesis (Pearson's ρ = 0) was rejected at a Benjamini-Hochberg false discovery rate of 0.2 in 15 of the 114 visit pairs, 11 of which exhibited positive correlations; even amongst these 11 visit pairs, correlations were modest (r in [0.30, 0.53]). The presented framework appears well suited to evaluating other potential imaging biomarkers of local GA growth rates. 2022-06-22T18:20:00Z 2022-06-22T18:20:00Z 2021 2022-06-22T18:14:16Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/143546 Moult, Eric M, Shi, Yingying, Zhang, Qinqin, Wang, Liang, Mazumder, Rahul et al. 2021. "Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits." Biomedical Optics Express, 12 (7). en 10.1364/BOE.427819 Biomedical Optics Express Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf The Optical Society Optica Publishing Group |
| spellingShingle | Moult, Eric M Shi, Yingying Zhang, Qinqin Wang, Liang Mazumder, Rahul Chen, Siyu Chu, Zhongdi Feuer, William Waheed, Nadia K Gregori, Giovanni Wang, Ruikang K Rosenfeld, Philip J Fujimoto, James G Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits |
| title | Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits |
| title_full | Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits |
| title_fullStr | Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits |
| title_full_unstemmed | Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits |
| title_short | Analysis of correlations between local geographic atrophy growth rates and local OCT angiography-measured choriocapillaris flow deficits |
| title_sort | analysis of correlations between local geographic atrophy growth rates and local oct angiography measured choriocapillaris flow deficits |
| url | https://hdl.handle.net/1721.1/143546 |
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