Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

<jats:title>Abstract</jats:title><jats:p>Mutational outcomes following CRISPR-Cas9-nuclease cutting in mammalian cells have recently been shown to be predictable and, in certain cases, skewed toward single genotypes. However, the ability to control these outcomes remains limited, e...

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Detalhes bibliográficos
Principais autores: Bermudez-Cabrera, Heysol C, Culbertson, Sannie, Barkal, Sammy, Holmes, Benjamin, Shen, Max W, Zhang, Sophia, Gifford, David K, Sherwood, Richard I
Outros Autores: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Formato: Artigo
Idioma:English
Publicado em: Springer Science and Business Media LLC 2022
Acesso em linha:https://hdl.handle.net/1721.1/143566

Internet

https://hdl.handle.net/1721.1/143566

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