Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

<jats:title>Abstract</jats:title><jats:p>Mutational outcomes following CRISPR-Cas9-nuclease cutting in mammalian cells have recently been shown to be predictable and, in certain cases, skewed toward single genotypes. However, the ability to control these outcomes remains limited, e...

Full description

Bibliographic Details
Main Authors: Bermudez-Cabrera, Heysol C, Culbertson, Sannie, Barkal, Sammy, Holmes, Benjamin, Shen, Max W, Zhang, Sophia, Gifford, David K, Sherwood, Richard I
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2022
Online Access:https://hdl.handle.net/1721.1/143566

Similar Items

Similar Items