Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo
<jats:title>Significance</jats:title> <jats:p> Bioelectronic medicine relies on electrical stimulation for most applications in the peripheral nervous system. It faces persistent challenges in selectively activating bundled nerve fibers. Here, we investigate...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Proceedings of the National Academy of Sciences
2022
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| Online Access: | https://hdl.handle.net/1721.1/143606 |
| _version_ | 1811094219742248960 |
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| author | Flavin, Matthew T Paul, Marek A Lim, Alexander S Lissandrello, Charles A Ajemian, Robert Lin, Samuel J Han, Jongyoon |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Flavin, Matthew T Paul, Marek A Lim, Alexander S Lissandrello, Charles A Ajemian, Robert Lin, Samuel J Han, Jongyoon |
| author_sort | Flavin, Matthew T |
| collection | MIT |
| description | <jats:title>Significance</jats:title>
<jats:p>
Bioelectronic medicine relies on electrical stimulation for most applications in the peripheral nervous system. It faces persistent challenges in selectively activating bundled nerve fibers. Here, we investigated ion-concentration modulation with ion-selective membranes and whether this modality may enhance the functional selectivity of peripheral nerve stimulation. We designed a multimodal stimulator that could control Ca
<jats:sup>2+</jats:sup>
concentrations within a focused volume. Acutely implanting it on the sciatic nerve of a rat, we demonstrated that Ca
<jats:sup>2+</jats:sup>
depletion could increase the sensitivity of the nerve to electrical stimulation in vivo. We provided evidence that it selectively influenced individual fascicles of the nerve, allowing selective activation by electrical current. Improved functional selectivity may improve outcomes for important therapeutic modalities.
</jats:p> |
| first_indexed | 2024-09-23T15:56:44Z |
| format | Article |
| id | mit-1721.1/143606 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:56:44Z |
| publishDate | 2022 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1436062023-02-16T19:07:27Z Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo Flavin, Matthew T Paul, Marek A Lim, Alexander S Lissandrello, Charles A Ajemian, Robert Lin, Samuel J Han, Jongyoon Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Biological Engineering <jats:title>Significance</jats:title> <jats:p> Bioelectronic medicine relies on electrical stimulation for most applications in the peripheral nervous system. It faces persistent challenges in selectively activating bundled nerve fibers. Here, we investigated ion-concentration modulation with ion-selective membranes and whether this modality may enhance the functional selectivity of peripheral nerve stimulation. We designed a multimodal stimulator that could control Ca <jats:sup>2+</jats:sup> concentrations within a focused volume. Acutely implanting it on the sciatic nerve of a rat, we demonstrated that Ca <jats:sup>2+</jats:sup> depletion could increase the sensitivity of the nerve to electrical stimulation in vivo. We provided evidence that it selectively influenced individual fascicles of the nerve, allowing selective activation by electrical current. Improved functional selectivity may improve outcomes for important therapeutic modalities. </jats:p> 2022-06-30T15:20:52Z 2022-06-30T15:20:52Z 2022-06-07 2022-06-30T15:16:07Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/143606 Flavin, Matthew T, Paul, Marek A, Lim, Alexander S, Lissandrello, Charles A, Ajemian, Robert et al. 2022. "Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo." Proceedings of the National Academy of Sciences, 119 (23). en 10.1073/pnas.2117764119 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Flavin, Matthew T Paul, Marek A Lim, Alexander S Lissandrello, Charles A Ajemian, Robert Lin, Samuel J Han, Jongyoon Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo |
| title | Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo |
| title_full | Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo |
| title_fullStr | Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo |
| title_full_unstemmed | Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo |
| title_short | Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo |
| title_sort | electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo |
| url | https://hdl.handle.net/1721.1/143606 |
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