Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity

<jats:p>The antimicrobial resistance crisis has rekindled interest in bacteriophage therapy. Phages have been studied over a century as therapeutics to treat bacterial infections, but one of the biggest challenges for the use of phages in therapeutic interventions remains their high specificit...

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Bibliographic Details
Main Authors: Latka, Agnieszka, Lemire, Sebastien, Grimon, Dennis, Dams, Dorien, Maciejewska, Barbara, Lu, Timothy, Drulis-Kawa, Zuzanna, Briers, Yves
Other Authors: Massachusetts Institute of Technology. Synthetic Biology Center
Format: Article
Language:English
Published: American Society for Microbiology 2022
Online Access:https://hdl.handle.net/1721.1/143757
Description
Summary:<jats:p>The antimicrobial resistance crisis has rekindled interest in bacteriophage therapy. Phages have been studied over a century as therapeutics to treat bacterial infections, but one of the biggest challenges for the use of phages in therapeutic interventions remains their high specificity.</jats:p>