Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition
Abstract Background Alzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an urgent need for development of both early diagnosis and the...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2022
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| Online Access: | https://hdl.handle.net/1721.1/143786 |
| _version_ | 1811076678990954496 |
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| author | Ruan, Yuting Xiong, Ying Fang, Wenli Yu, Qun Mai, Yingren Cao, Zhiyu Wang, Kexi Lei, Ming Xu, Jiaxin Liu, Yan Zhang, Xingcai Liao, Wang Liu, Jun |
| author2 | Massachusetts Institute of Technology. Research Laboratory of Electronics |
| author_facet | Massachusetts Institute of Technology. Research Laboratory of Electronics Ruan, Yuting Xiong, Ying Fang, Wenli Yu, Qun Mai, Yingren Cao, Zhiyu Wang, Kexi Lei, Ming Xu, Jiaxin Liu, Yan Zhang, Xingcai Liao, Wang Liu, Jun |
| author_sort | Ruan, Yuting |
| collection | MIT |
| description | Abstract
Background
Alzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an urgent need for development of both early diagnosis and therapeutic intervention of AD.
Results
Herein, we developed a nanotheranostics platform consisting of Curcumin (Cur), an anti-inflammatory molecule, and superparamagnetic iron oxide (SPIO) nanoparticles encapsulated by diblock 1,2-dio-leoyl-sn-glycero-3-phosphoethanolamine-n-[poly(ethylene glycol)] (DSPE-PEG) that are modified with CRT and QSH peptides on its surface. Furthermore, we demonstrated that this multifunctional nanomaterial efficiently reduced β-amyloid plaque burden specifically in APP/PS1 transgenic mice, with the process noninvasively detected by magnetic resonance imaging (MRI) and the two-dimensional MRI images were computed into three-dimension (3D) plot. Our data demonstrated highly sensitive in vivo detection of β-amyloid plaques which more closely revealed real deposition of Aβ than previously reported and we quantified the volumes of plaques for the first time based on 3D plot. In addition, memory deficits of the mice were significantly rescued, probably related to inhibition of NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasomes.
Conclusions
Gathered data demonstrated that this theranostic platform may have both early diagnostic and therapeutic potential in AD.
Graphical Abstract |
| first_indexed | 2024-09-23T10:25:51Z |
| format | Article |
| id | mit-1721.1/143786 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:25:51Z |
| publishDate | 2022 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | mit-1721.1/1437862023-04-18T19:40:34Z Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition Ruan, Yuting Xiong, Ying Fang, Wenli Yu, Qun Mai, Yingren Cao, Zhiyu Wang, Kexi Lei, Ming Xu, Jiaxin Liu, Yan Zhang, Xingcai Liao, Wang Liu, Jun Massachusetts Institute of Technology. Research Laboratory of Electronics Abstract Background Alzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an urgent need for development of both early diagnosis and therapeutic intervention of AD. Results Herein, we developed a nanotheranostics platform consisting of Curcumin (Cur), an anti-inflammatory molecule, and superparamagnetic iron oxide (SPIO) nanoparticles encapsulated by diblock 1,2-dio-leoyl-sn-glycero-3-phosphoethanolamine-n-[poly(ethylene glycol)] (DSPE-PEG) that are modified with CRT and QSH peptides on its surface. Furthermore, we demonstrated that this multifunctional nanomaterial efficiently reduced β-amyloid plaque burden specifically in APP/PS1 transgenic mice, with the process noninvasively detected by magnetic resonance imaging (MRI) and the two-dimensional MRI images were computed into three-dimension (3D) plot. Our data demonstrated highly sensitive in vivo detection of β-amyloid plaques which more closely revealed real deposition of Aβ than previously reported and we quantified the volumes of plaques for the first time based on 3D plot. In addition, memory deficits of the mice were significantly rescued, probably related to inhibition of NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasomes. Conclusions Gathered data demonstrated that this theranostic platform may have both early diagnostic and therapeutic potential in AD. Graphical Abstract 2022-07-18T12:06:31Z 2022-07-18T12:06:31Z 2022-07-14 2022-07-17T03:16:08Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/143786 Journal of Nanobiotechnology. 2022 Jul 14;20(1):322 PUBLISHER_CC en https://doi.org/10.1186/s12951-022-01524-4 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ The Author(s) application/pdf BioMed Central BioMed Central |
| spellingShingle | Ruan, Yuting Xiong, Ying Fang, Wenli Yu, Qun Mai, Yingren Cao, Zhiyu Wang, Kexi Lei, Ming Xu, Jiaxin Liu, Yan Zhang, Xingcai Liao, Wang Liu, Jun Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition |
| title | Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition |
| title_full | Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition |
| title_fullStr | Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition |
| title_full_unstemmed | Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition |
| title_short | Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition |
| title_sort | highly sensitive curcumin conjugated nanotheranostic platform for detecting amyloid beta plaques by magnetic resonance imaging and reversing cognitive deficits of alzheimer s disease via nlrp3 inhibition |
| url | https://hdl.handle.net/1721.1/143786 |
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