Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering
Despite rigorous research, inferior mechanical properties and structural homogeneity are the main challenges constraining hydrogel's suturability to host tissue and limiting its clinical applications. To tackle those, we developed a reverse solvent interface trapping method, in which organized,...
| Main Authors: | , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS)
2022
|
| Online Access: | https://hdl.handle.net/1721.1/143968 |
| _version_ | 1811091177073541120 |
|---|---|
| author | Sharifi, Sina Sharifi, Hannah Akbari, Ali Dohlman, Claes H Paschalis, Eleftherios I Gonzalez-Andrades, Miguel Kong, Jing Chodosh, James |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Sharifi, Sina Sharifi, Hannah Akbari, Ali Dohlman, Claes H Paschalis, Eleftherios I Gonzalez-Andrades, Miguel Kong, Jing Chodosh, James |
| author_sort | Sharifi, Sina |
| collection | MIT |
| description | Despite rigorous research, inferior mechanical properties and structural homogeneity are the main challenges constraining hydrogel's suturability to host tissue and limiting its clinical applications. To tackle those, we developed a reverse solvent interface trapping method, in which organized, graphene-coated microspherical cavities were introduced into a hydrogel to create heterogeneity and make it suturable. To generate those cavities, (i) graphite exfoliates to graphene sheets, which spread at the water/ heptane interfaces of the microemulsion, (ii) heptane fills the microspheres coated by graphene, and (iii) a cross-linkable hydrogel dissolved in water fills the voids. Cross-linking solidifies such microemulsion to a strong, suturable, permanent hybrid architecture, which has better mechanical properties, yet it is biocompatible and supports cell adhesion and proliferation. These properties along with the ease and biosafety of fabrication suggest the potential of this strategy to enhance tissue engineering outcomes by generating various suturable scaffolds for biomedical applications, such as donor cornea carriers for Boston keratoprosthesis (BK). |
| first_indexed | 2024-09-23T14:58:10Z |
| format | Article |
| id | mit-1721.1/143968 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:58:10Z |
| publishDate | 2022 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1439682023-06-30T18:49:29Z Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering Sharifi, Sina Sharifi, Hannah Akbari, Ali Dohlman, Claes H Paschalis, Eleftherios I Gonzalez-Andrades, Miguel Kong, Jing Chodosh, James Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Despite rigorous research, inferior mechanical properties and structural homogeneity are the main challenges constraining hydrogel's suturability to host tissue and limiting its clinical applications. To tackle those, we developed a reverse solvent interface trapping method, in which organized, graphene-coated microspherical cavities were introduced into a hydrogel to create heterogeneity and make it suturable. To generate those cavities, (i) graphite exfoliates to graphene sheets, which spread at the water/ heptane interfaces of the microemulsion, (ii) heptane fills the microspheres coated by graphene, and (iii) a cross-linkable hydrogel dissolved in water fills the voids. Cross-linking solidifies such microemulsion to a strong, suturable, permanent hybrid architecture, which has better mechanical properties, yet it is biocompatible and supports cell adhesion and proliferation. These properties along with the ease and biosafety of fabrication suggest the potential of this strategy to enhance tissue engineering outcomes by generating various suturable scaffolds for biomedical applications, such as donor cornea carriers for Boston keratoprosthesis (BK). 2022-07-22T15:10:29Z 2022-07-22T15:10:29Z 2021 2022-07-22T15:02:25Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/143968 Sharifi, Sina, Sharifi, Hannah, Akbari, Ali, Dohlman, Claes H, Paschalis, Eleftherios I et al. 2021. "Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering." ACS Applied Nano Materials, 4 (11). en 10.1021/ACSANM.1C03201 ACS Applied Nano Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Sharifi, Sina Sharifi, Hannah Akbari, Ali Dohlman, Claes H Paschalis, Eleftherios I Gonzalez-Andrades, Miguel Kong, Jing Chodosh, James Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering |
| title | Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering |
| title_full | Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering |
| title_fullStr | Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering |
| title_full_unstemmed | Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering |
| title_short | Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering |
| title_sort | graphene lined porous gelatin glycidyl methacrylate hydrogels implications for tissue engineering |
| url | https://hdl.handle.net/1721.1/143968 |
| work_keys_str_mv | AT sharifisina graphenelinedporousgelatinglycidylmethacrylatehydrogelsimplicationsfortissueengineering AT sharifihannah graphenelinedporousgelatinglycidylmethacrylatehydrogelsimplicationsfortissueengineering AT akbariali graphenelinedporousgelatinglycidylmethacrylatehydrogelsimplicationsfortissueengineering AT dohlmanclaesh graphenelinedporousgelatinglycidylmethacrylatehydrogelsimplicationsfortissueengineering AT paschaliseleftheriosi graphenelinedporousgelatinglycidylmethacrylatehydrogelsimplicationsfortissueengineering AT gonzalezandradesmiguel graphenelinedporousgelatinglycidylmethacrylatehydrogelsimplicationsfortissueengineering AT kongjing graphenelinedporousgelatinglycidylmethacrylatehydrogelsimplicationsfortissueengineering AT chodoshjames graphenelinedporousgelatinglycidylmethacrylatehydrogelsimplicationsfortissueengineering |