Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study
This study evaluates the association of anthropometric indexes and the incidence of type 2 diabetes mellitus (T2DM) after a 5-year follow-up. This analysis included 1091 middle-aged participants (57% women, mean age 47 ± 15 years) who were free of T2DM at baseline and attended two health examination...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Public Library of Science (PLoS)
2022
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| Online Access: | https://hdl.handle.net/1721.1/144116 |
| _version_ | 1826202498541551616 |
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| author | de Oliveira, Camila Maciel Pavani, Jessica Leticia Liu, Chunyu Balcells, Mercedes Capasso, Robson Alvim, Rafael de Oliveira Mourão-Júnior, Carlos Alberto Krieger, José Eduardo Pereira, Alexandre Costa |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science de Oliveira, Camila Maciel Pavani, Jessica Leticia Liu, Chunyu Balcells, Mercedes Capasso, Robson Alvim, Rafael de Oliveira Mourão-Júnior, Carlos Alberto Krieger, José Eduardo Pereira, Alexandre Costa |
| author_sort | de Oliveira, Camila Maciel |
| collection | MIT |
| description | This study evaluates the association of anthropometric indexes and the incidence of type 2 diabetes mellitus (T2DM) after a 5-year follow-up. This analysis included 1091 middle-aged participants (57% women, mean age 47 ± 15 years) who were free of T2DM at baseline and attended two health examinations cycles [cycle 1 (2005–2006) and cycle 2 (2010–2013)]. As expected, the participants who developed T2DM after five years (3.8%) had the worst metabolic profile with higher hypertension, dyslipidemia, and obesity rates. Besides, using mixed-effects logistic regression and adjustment for sex, age, and glucose, we found that one unit increase in body adiposity index (BAI) was associated with an 8% increase in their risk of developing T2DM (odds ratio [OR] = 1.08 [95% CI, 1.02–1.14]) and visceral adiposity index (VAI) was associated with a risk increase of 11% (OR = 1.11 [95% CI, 1.00–1.22]). Moreover, a one-unit increase in the triglycerides-glucose index (TyG) was associated with more than four times the risk of developing T2DM (OR = 4.27 [95% CI, 1.01–17.97]). The interquartile range odds ratio for the continuous predictors showed that TyG had the best discriminating performance. However, when any of them were additionally adjusted for waist circumference (WC) or even body mass index (BMI), all adiposity indexes lost the effect in predicting T2DM. In conclusion, TyG had the most substantial predictive power among all three indexes. However, neither BAI, VAI, nor TyG were superior to WC or BMI for predicting the risk of developing T2DM in a middle-aged normoglycemic sample in this rural Brazilian population. |
| first_indexed | 2024-09-23T12:08:27Z |
| format | Article |
| id | mit-1721.1/144116 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:08:27Z |
| publishDate | 2022 |
| publisher | Public Library of Science (PLoS) |
| record_format | dspace |
| spelling | mit-1721.1/1441162024-03-19T14:24:27Z Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study de Oliveira, Camila Maciel Pavani, Jessica Leticia Liu, Chunyu Balcells, Mercedes Capasso, Robson Alvim, Rafael de Oliveira Mourão-Júnior, Carlos Alberto Krieger, José Eduardo Pereira, Alexandre Costa Massachusetts Institute of Technology. Institute for Medical Engineering & Science This study evaluates the association of anthropometric indexes and the incidence of type 2 diabetes mellitus (T2DM) after a 5-year follow-up. This analysis included 1091 middle-aged participants (57% women, mean age 47 ± 15 years) who were free of T2DM at baseline and attended two health examinations cycles [cycle 1 (2005–2006) and cycle 2 (2010–2013)]. As expected, the participants who developed T2DM after five years (3.8%) had the worst metabolic profile with higher hypertension, dyslipidemia, and obesity rates. Besides, using mixed-effects logistic regression and adjustment for sex, age, and glucose, we found that one unit increase in body adiposity index (BAI) was associated with an 8% increase in their risk of developing T2DM (odds ratio [OR] = 1.08 [95% CI, 1.02–1.14]) and visceral adiposity index (VAI) was associated with a risk increase of 11% (OR = 1.11 [95% CI, 1.00–1.22]). Moreover, a one-unit increase in the triglycerides-glucose index (TyG) was associated with more than four times the risk of developing T2DM (OR = 4.27 [95% CI, 1.01–17.97]). The interquartile range odds ratio for the continuous predictors showed that TyG had the best discriminating performance. However, when any of them were additionally adjusted for waist circumference (WC) or even body mass index (BMI), all adiposity indexes lost the effect in predicting T2DM. In conclusion, TyG had the most substantial predictive power among all three indexes. However, neither BAI, VAI, nor TyG were superior to WC or BMI for predicting the risk of developing T2DM in a middle-aged normoglycemic sample in this rural Brazilian population. 2022-07-29T12:08:39Z 2022-07-29T12:08:39Z 2022-06-03 Article http://purl.org/eprint/type/JournalArticle 1932-6203 https://hdl.handle.net/1721.1/144116 de Oliveira, Camila Maciel, Pavani, Jessica Leticia, Liu, Chunyu, Balcells, Mercedes, Capasso, Robson et al. 2022. "Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study." 17 (6). 10.1371/journal.pone.0267723 Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science (PLoS) PLoS |
| spellingShingle | de Oliveira, Camila Maciel Pavani, Jessica Leticia Liu, Chunyu Balcells, Mercedes Capasso, Robson Alvim, Rafael de Oliveira Mourão-Júnior, Carlos Alberto Krieger, José Eduardo Pereira, Alexandre Costa Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study |
| title | Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study |
| title_full | Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study |
| title_fullStr | Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study |
| title_full_unstemmed | Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study |
| title_short | Comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow-up cohort: The Baependi Heart Study |
| title_sort | comparing different metabolic indexes to predict type 2 diabetes mellitus in a five years follow up cohort the baependi heart study |
| url | https://hdl.handle.net/1721.1/144116 |
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