Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems
Abstract Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intestinal absorption is rapid clearance of the drug and the drug deliver...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2022
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| Online Access: | https://hdl.handle.net/1721.1/144258 |
| _version_ | 1811083367585677312 |
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| author | Subramanian, Deepak A. Langer, Robert Traverso, Giovanni |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Subramanian, Deepak A. Langer, Robert Traverso, Giovanni |
| author_sort | Subramanian, Deepak A. |
| collection | MIT |
| description | Abstract
Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intestinal absorption is rapid clearance of the drug and the drug delivery system from the gastrointestinal (GI) tract. To address this issue, researchers have investigated using GI mucus to help maximize the pharmacokinetics of the therapeutic; while mucus can act as a barrier to effective oral delivery, it can also be used as an anchoring mechanism to improve intestinal residence. Nano-drug delivery systems that use materials which can interact with the mucus layers in the GI tract can enable longer residence time, improving the efficacy of oral drug delivery. This review examines the properties and function of mucus in the GI tract, as well as diseases that alter mucus. Three broad classes of mucus-interacting systems are discussed: mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems. For each class of system, the basis for mucus interaction is presented, and examples of materials that inform the development of these systems are discussed and reviewed. Finally, a list of FDA-approved mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems is reviewed. In summary, this review highlights the progress made in developing mucus-interacting systems, both at a research-scale and commercial-scale level, and describes the theoretical basis for each type of system. |
| first_indexed | 2024-09-23T12:31:56Z |
| format | Article |
| id | mit-1721.1/144258 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:31:56Z |
| publishDate | 2022 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | mit-1721.1/1442582023-07-19T20:16:59Z Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems Subramanian, Deepak A. Langer, Robert Traverso, Giovanni Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Abstract Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intestinal absorption is rapid clearance of the drug and the drug delivery system from the gastrointestinal (GI) tract. To address this issue, researchers have investigated using GI mucus to help maximize the pharmacokinetics of the therapeutic; while mucus can act as a barrier to effective oral delivery, it can also be used as an anchoring mechanism to improve intestinal residence. Nano-drug delivery systems that use materials which can interact with the mucus layers in the GI tract can enable longer residence time, improving the efficacy of oral drug delivery. This review examines the properties and function of mucus in the GI tract, as well as diseases that alter mucus. Three broad classes of mucus-interacting systems are discussed: mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems. For each class of system, the basis for mucus interaction is presented, and examples of materials that inform the development of these systems are discussed and reviewed. Finally, a list of FDA-approved mucoadhesive, mucus-penetrating, and mucolytic drug delivery systems is reviewed. In summary, this review highlights the progress made in developing mucus-interacting systems, both at a research-scale and commercial-scale level, and describes the theoretical basis for each type of system. 2022-08-08T12:18:25Z 2022-08-08T12:18:25Z 2022-08-06 2022-08-07T03:12:12Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/144258 Journal of Nanobiotechnology. 2022 Aug 06;20(1):362 PUBLISHER_CC en https://doi.org/10.1186/s12951-022-01539-x Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ The Author(s) application/pdf BioMed Central BioMed Central |
| spellingShingle | Subramanian, Deepak A. Langer, Robert Traverso, Giovanni Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems |
| title | Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems |
| title_full | Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems |
| title_fullStr | Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems |
| title_full_unstemmed | Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems |
| title_short | Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems |
| title_sort | mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano drug delivery systems |
| url | https://hdl.handle.net/1721.1/144258 |
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