Exploring the Activation Landscape of Pro-Apoptotic BAK Through the Discovery of Human BH3-Only and Non-Native Peptide Binders
BAK is one of the two pro-apoptotic members that form part of the BCL-2 protein family. Previous work has shown that binding of certain BH3-only proteins such as truncated BID (tBID), BIM, and PUMA to pro-apoptotic BAK leads to mitochondrial outer membrane permeabilization (MOMP), release of cytochr...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Published: |
Massachusetts Institute of Technology
2022
|
| Online Access: | https://hdl.handle.net/1721.1/144855 https://orcid.org/ 0000-0002-0596-7486 |