An ORC Flip Enables Bidirectional Helicase Loading
Cells must duplicate their genetic material faithfully in every cell cycle to maintain cellular identity and ensure viability. The first step in DNA replication is the licensing of all potential origins by loading two inactive Mcm2-7 replicative DNA helicases around the origin DNA in a head-to-head...
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/145064 https://orcid.org/0000-0002-5446-7912 |