Discovery of microenvironment drivers of cell states, plasticity and drug response
Cell state can be influenced by both intrinsic and extrinsic factors with functional consequences. Illustratively, in cancer, intrinsic genome level alterations or extrinsic microenvironmental immune cell activity can drive tumorigenesis. Similarly, in viral infections like COVID-19, the responses o...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2022
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| Online Access: | https://hdl.handle.net/1721.1/145131 |