Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T
Abstract Objectives Wave-CAIPI (Controlled Aliasing in Parallel Imaging) enables dramatic reduction in acquisition time of 3D MRI sequences such as 3D susceptibility-weighted imaging (SWI) but has not been clinically evaluated at 1.5 T. We sought to...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Berlin Heidelberg
2022
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| Online Access: | https://hdl.handle.net/1721.1/145422 |
| _version_ | 1826198814748311552 |
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| author | Conklin, John Figueiro Longo, Maria G. Tabari, Azadeh Lio Goncalves Filho, Augusto Liu, Wei Splitthoff, Daniel N. Lo, Wei-Ching Cauley, Stephen F. Setsompop, Kawin Schaefer, Pamela W. Kirsch, John E. Rapalino, Otto Huang, Susie Y. |
| author2 | Harvard-MIT Program in Health Sciences and Technology |
| author_facet | Harvard-MIT Program in Health Sciences and Technology Conklin, John Figueiro Longo, Maria G. Tabari, Azadeh Lio Goncalves Filho, Augusto Liu, Wei Splitthoff, Daniel N. Lo, Wei-Ching Cauley, Stephen F. Setsompop, Kawin Schaefer, Pamela W. Kirsch, John E. Rapalino, Otto Huang, Susie Y. |
| author_sort | Conklin, John |
| collection | MIT |
| description | Abstract
Objectives
Wave-CAIPI (Controlled Aliasing in Parallel Imaging) enables dramatic reduction in acquisition time of 3D MRI sequences such as 3D susceptibility-weighted imaging (SWI) but has not been clinically evaluated at 1.5 T. We sought to compare highly accelerated Wave-CAIPI SWI (Wave-SWI) with two alternative standard sequences, conventional three-dimensional SWI and two-dimensional T2*-weighted Gradient-Echo (T2*w-GRE), in patients undergoing routine brain MRI at 1.5 T.
Methods
In this study, 172 patients undergoing 1.5 T brain MRI were scanned with a more commonly used susceptibility sequence (standard SWI or T2*w-GRE) and a highly accelerated Wave-SWI sequence. Two radiologists blinded to the acquisition technique scored each sequence for visualization of pathology, motion and signal dropout artifacts, image noise, visualization of normal anatomy (vessels and basal ganglia mineralization), and overall diagnostic quality. Superiority testing was performed to compare Wave-SWI to T2*w-GRE, and non-inferiority testing with 15% margin was performed to compare Wave-SWI to standard SWI.
Results
Wave-SWI performed superior in terms of visualization of pathology, signal dropout artifacts, visualization of normal anatomy, and overall image quality when compared to T2*w-GRE (all p < 0.001). Wave-SWI was non-inferior to standard SWI for visualization of normal anatomy and pathology, signal dropout artifacts, and overall image quality (all p < 0.001). Wave-SWI was superior to standard SWI for motion artifact (p < 0.001), while both conventional susceptibility sequences were superior to Wave-SWI for image noise (p < 0.001).
Conclusions
Wave-SWI can be performed in a 1.5 T clinical setting with robust performance and preservation of diagnostic quality.
Key Points
• Wave-SWI accelerated the acquisition of 3D high-resolution susceptibility images in 70% of the acquisition time of the conventional T2*GRE.
• Wave-SWI performed superior to T2*w-GRE for visualization of pathology, signal dropout artifacts, and overall diagnostic image quality.
• Wave-SWI was noninferior to standard SWI for visualization of normal anatomy and pathology, signal dropout artifacts, and overall diagnostic image quality. |
| first_indexed | 2024-09-23T11:10:27Z |
| format | Article |
| id | mit-1721.1/145422 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:10:27Z |
| publishDate | 2022 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | mit-1721.1/1454222023-08-14T05:22:58Z Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T Conklin, John Figueiro Longo, Maria G. Tabari, Azadeh Lio Goncalves Filho, Augusto Liu, Wei Splitthoff, Daniel N. Lo, Wei-Ching Cauley, Stephen F. Setsompop, Kawin Schaefer, Pamela W. Kirsch, John E. Rapalino, Otto Huang, Susie Y. Harvard-MIT Program in Health Sciences and Technology Abstract Objectives Wave-CAIPI (Controlled Aliasing in Parallel Imaging) enables dramatic reduction in acquisition time of 3D MRI sequences such as 3D susceptibility-weighted imaging (SWI) but has not been clinically evaluated at 1.5 T. We sought to compare highly accelerated Wave-CAIPI SWI (Wave-SWI) with two alternative standard sequences, conventional three-dimensional SWI and two-dimensional T2*-weighted Gradient-Echo (T2*w-GRE), in patients undergoing routine brain MRI at 1.5 T. Methods In this study, 172 patients undergoing 1.5 T brain MRI were scanned with a more commonly used susceptibility sequence (standard SWI or T2*w-GRE) and a highly accelerated Wave-SWI sequence. Two radiologists blinded to the acquisition technique scored each sequence for visualization of pathology, motion and signal dropout artifacts, image noise, visualization of normal anatomy (vessels and basal ganglia mineralization), and overall diagnostic quality. Superiority testing was performed to compare Wave-SWI to T2*w-GRE, and non-inferiority testing with 15% margin was performed to compare Wave-SWI to standard SWI. Results Wave-SWI performed superior in terms of visualization of pathology, signal dropout artifacts, visualization of normal anatomy, and overall image quality when compared to T2*w-GRE (all p < 0.001). Wave-SWI was non-inferior to standard SWI for visualization of normal anatomy and pathology, signal dropout artifacts, and overall image quality (all p < 0.001). Wave-SWI was superior to standard SWI for motion artifact (p < 0.001), while both conventional susceptibility sequences were superior to Wave-SWI for image noise (p < 0.001). Conclusions Wave-SWI can be performed in a 1.5 T clinical setting with robust performance and preservation of diagnostic quality. Key Points • Wave-SWI accelerated the acquisition of 3D high-resolution susceptibility images in 70% of the acquisition time of the conventional T2*GRE. • Wave-SWI performed superior to T2*w-GRE for visualization of pathology, signal dropout artifacts, and overall diagnostic image quality. • Wave-SWI was noninferior to standard SWI for visualization of normal anatomy and pathology, signal dropout artifacts, and overall diagnostic image quality. 2022-09-15T12:02:42Z 2022-09-15T12:02:42Z 2022-08-04 2022-09-15T03:22:15Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/145422 Conklin, J., Figueiro Longo, M.G., Tabari, A. et al. Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T. Eur Radiol 32, 7128–7135 (2022). en https://doi.org/10.1007/s00330-022-08871-8 European Radiology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The Author(s), under exclusive licence to European Society of Radiology application/pdf Springer Berlin Heidelberg Springer Berlin Heidelberg |
| spellingShingle | Conklin, John Figueiro Longo, Maria G. Tabari, Azadeh Lio Goncalves Filho, Augusto Liu, Wei Splitthoff, Daniel N. Lo, Wei-Ching Cauley, Stephen F. Setsompop, Kawin Schaefer, Pamela W. Kirsch, John E. Rapalino, Otto Huang, Susie Y. Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T |
| title | Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T |
| title_full | Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T |
| title_fullStr | Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T |
| title_full_unstemmed | Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T |
| title_short | Clinical validation of Wave-CAIPI susceptibility-weighted imaging for routine brain MRI at 1.5 T |
| title_sort | clinical validation of wave caipi susceptibility weighted imaging for routine brain mri at 1 5 t |
| url | https://hdl.handle.net/1721.1/145422 |
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