Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials
There is a compelling need across several industries to substitute non-degradable, intentionally added microplastics with biodegradable alternatives. Nonetheless, stringent performance criteria in actives' controlled release and manufacturing at scale of emerging materials hinder the replacemen...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022
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| Online Access: | https://hdl.handle.net/1721.1/145702 |
| _version_ | 1811069234333089792 |
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| author | Liu, Muchun Millard, Pierre‐Eric Urch, Henning Zeyons, Ophelie Findley, Douglas Konradi, Rupert Marelli, Benedetto |
| author2 | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Liu, Muchun Millard, Pierre‐Eric Urch, Henning Zeyons, Ophelie Findley, Douglas Konradi, Rupert Marelli, Benedetto |
| author_sort | Liu, Muchun |
| collection | MIT |
| description | There is a compelling need across several industries to substitute non-degradable, intentionally added microplastics with biodegradable alternatives. Nonetheless, stringent performance criteria in actives' controlled release and manufacturing at scale of emerging materials hinder the replacement of polymers used for microplastics fabrication with circular ones. Here, the authors demonstrate that active microencapsulation in a structural protein such as silk fibroin can be achieved by modulating protein protonation and chain relaxation at the point of material assembly. Silk fibroin micelles' size is tuned from several to hundreds of nanometers, enabling the manufacturing-by retrofitting spray drying and spray freeze drying techniques-of microcapsules with tunable morphology and structure, that is, hollow-spongy, hollow-smooth, hollow crumpled matrices, and hollow crumpled multi-domain. Microcapsules degradation kinetics and sustained release of soluble and insoluble payloads typically used in cosmetic and agriculture applications are controlled by modulating fibroin's beta-sheet content from 20% to near 40%. Ultraviolet-visible studies indicate that burst release of a commonly used herbicide (i.e., saflufenacil) significantly decreases from 25% to 0.8% via silk fibroin microencapsulation. As a proof-of-concept for agrochemicals applications, a 6-day greenhouse trial demonstrates that saflufenacil delivered on corn plants via silk microcapsules reduces crop injury when compared to the non-encapsulated version. |
| first_indexed | 2024-09-23T08:07:51Z |
| format | Article |
| id | mit-1721.1/145702 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:07:51Z |
| publishDate | 2022 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1457022022-10-07T03:48:44Z Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials Liu, Muchun Millard, Pierre‐Eric Urch, Henning Zeyons, Ophelie Findley, Douglas Konradi, Rupert Marelli, Benedetto Massachusetts Institute of Technology. Department of Civil and Environmental Engineering There is a compelling need across several industries to substitute non-degradable, intentionally added microplastics with biodegradable alternatives. Nonetheless, stringent performance criteria in actives' controlled release and manufacturing at scale of emerging materials hinder the replacement of polymers used for microplastics fabrication with circular ones. Here, the authors demonstrate that active microencapsulation in a structural protein such as silk fibroin can be achieved by modulating protein protonation and chain relaxation at the point of material assembly. Silk fibroin micelles' size is tuned from several to hundreds of nanometers, enabling the manufacturing-by retrofitting spray drying and spray freeze drying techniques-of microcapsules with tunable morphology and structure, that is, hollow-spongy, hollow-smooth, hollow crumpled matrices, and hollow crumpled multi-domain. Microcapsules degradation kinetics and sustained release of soluble and insoluble payloads typically used in cosmetic and agriculture applications are controlled by modulating fibroin's beta-sheet content from 20% to near 40%. Ultraviolet-visible studies indicate that burst release of a commonly used herbicide (i.e., saflufenacil) significantly decreases from 25% to 0.8% via silk fibroin microencapsulation. As a proof-of-concept for agrochemicals applications, a 6-day greenhouse trial demonstrates that saflufenacil delivered on corn plants via silk microcapsules reduces crop injury when compared to the non-encapsulated version. 2022-10-06T13:42:02Z 2022-10-06T13:42:02Z 2022-08 2022-10-06T13:29:47Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/145702 Liu, Muchun, Millard, Pierre‐Eric, Urch, Henning, Zeyons, Ophelie, Findley, Douglas et al. 2022. "Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials." Small, 18 (31). en 10.1002/smll.202201487 Small Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Liu, Muchun Millard, Pierre‐Eric Urch, Henning Zeyons, Ophelie Findley, Douglas Konradi, Rupert Marelli, Benedetto Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials |
| title | Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials |
| title_full | Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials |
| title_fullStr | Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials |
| title_full_unstemmed | Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials |
| title_short | Microencapsulation of High‐Content Actives Using Biodegradable Silk Materials |
| title_sort | microencapsulation of high content actives using biodegradable silk materials |
| url | https://hdl.handle.net/1721.1/145702 |
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