Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
The implementation of self-optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self-optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemic...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022
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| Online Access: | https://hdl.handle.net/1721.1/145714 |
| _version_ | 1811069880383832064 |
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| author | Gérardy, Romaric Nambiar, Anirudh MK Hart, Travis Mahesh, Prajwal T Jensen, Klavs F |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Gérardy, Romaric Nambiar, Anirudh MK Hart, Travis Mahesh, Prajwal T Jensen, Klavs F |
| author_sort | Gérardy, Romaric |
| collection | MIT |
| description | The implementation of self-optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self-optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C-C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization. |
| first_indexed | 2024-09-23T08:18:26Z |
| format | Article |
| id | mit-1721.1/145714 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:18:26Z |
| publishDate | 2022 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1457142022-10-07T03:47:20Z Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform Gérardy, Romaric Nambiar, Anirudh MK Hart, Travis Mahesh, Prajwal T Jensen, Klavs F Massachusetts Institute of Technology. Department of Chemical Engineering The implementation of self-optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self-optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C-C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization. 2022-10-06T15:49:36Z 2022-10-06T15:49:36Z 2022-08 2022-10-06T15:44:13Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/145714 Gérardy, Romaric, Nambiar, Anirudh MK, Hart, Travis, Mahesh, Prajwal T and Jensen, Klavs F. 2022. "Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform." Chemistry – A European Journal, 28 (43). en 10.1002/chem.202201385 Chemistry – A European Journal Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf Wiley Wiley |
| spellingShingle | Gérardy, Romaric Nambiar, Anirudh MK Hart, Travis Mahesh, Prajwal T Jensen, Klavs F Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform |
| title | Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform |
| title_full | Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform |
| title_fullStr | Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform |
| title_full_unstemmed | Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform |
| title_short | Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform |
| title_sort | photochemical synthesis of the bioactive fragment of salbutamol and derivatives in a self optimizing flow chemistry platform |
| url | https://hdl.handle.net/1721.1/145714 |
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