Highly protective antimalarial antibodies via precision library generation and yeast display screening

Highly protective antimalarial antibodies via precision library generation and yeast display screening

<jats:p>The monoclonal antibody CIS43 targets the Plasmodium falciparum circumsporozoite protein (PfCSP) and prevents malaria infection in humans for up to 9 mo following a single intravenous administration. To enhance the potency and clinical utility of CIS43, we used iterative site-saturatio...

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Bibliographic Details
Main Authors: Banach, Bailey B, Tripathi, Prabhanshu, Da Silva Pereira, Lais, Gorman, Jason, Nguyen, Thuy Duong, Dillon, Marlon, Fahad, Ahmed S, Kiyuka, Patience K, Madan, Bharat, Wolfe, Jacy R, Bonilla, Brian, Flynn, Barbara, Francica, Joseph R, Hurlburt, Nicholas K, Kisalu, Neville K, Liu, Tracy, Ou, Li, Rawi, Reda, Schön, Arne, Shen, Chen-Hsiang, Teng, I-Ting, Zhang, Baoshan, Pancera, Marie, Idris, Azza H, Seder, Robert A, Kwong, Peter D, DeKosky, Brandon J
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Rockefeller University Press 2022
Online Access:https://hdl.handle.net/1721.1/145918

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