VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients

VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients

Abstract The ovarian tumor microenvironment (TME) is characterized by the accumulation of immunosuppressive tumor-associated macrophages (TAMs) and granulocytic cells. Very small size particles (VSSP), comprised of the ganglioside NAcGM3 and Neisseria meningitidis derived outer membra...

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Bibliographic Details
Main Authors: Khan, ANM N. H., Emmons, Tiffany R., Magner, William J., Alqassim, Emad, Singel, Kelly L., Ricciuti, Jason, Eng, Kevin H., Odunsi, Kunle, Tomasi, Thomas B., Lee, Kelvin, Abrams, Scott I., Mesa, Circe, Segal, Brahm H.
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer Berlin Heidelberg 2022
Online Access:https://hdl.handle.net/1721.1/145935

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