Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer
Abstract In the past two decades, the emergence of nanomaterials for biomedical applications has shown tremendous promise for changing the paradigm of all aspects of disease management. Nanomaterials are particularly attractive for being a modularly tunable system; with the ability to...
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| Format: | Article |
| Language: | English |
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Springer International Publishing
2022
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| Online Access: | https://hdl.handle.net/1721.1/145941 |
| _version_ | 1826205177614434304 |
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| author | Bardhan, Neelkanth |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Bardhan, Neelkanth |
| author_sort | Bardhan, Neelkanth |
| collection | MIT |
| description | Abstract
In the past two decades, the emergence of nanomaterials for biomedical applications has shown tremendous promise for changing the paradigm of all aspects of disease management. Nanomaterials are particularly attractive for being a modularly tunable system; with the ability to add functionality for early diagnostics, drug delivery, therapy, treatment and monitoring of patient response. In this review, a survey of the landscape of different classes of nanomaterials being developed for applications in diagnostics and imaging, as well as for the delivery of prophylactic vaccines and therapeutics such as small molecules and biologic drugs is undertaken; with a particular focus on COVID-19 diagnostics and vaccination. Work involving bio-templated nanomaterials for high-resolution imaging applications for early cancer detection, as well as for optimal cancer treatment efficacy, is discussed. The main challenges which need to be overcome from the standpoint of effective delivery and mitigating toxicity concerns are investigated. Subsequently, a section is included with resources for researchers and practitioners in nanomedicine, to help tailor their designs and formulations from a clinical perspective. Finally, three key areas for researchers to focus on are highlighted; to accelerate the development and clinical translation of these nanomaterials, thereby unleashing the true potential of nanomedicine in healthcare.
Graphical abstract |
| first_indexed | 2024-09-23T13:08:37Z |
| format | Article |
| id | mit-1721.1/145941 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:08:37Z |
| publishDate | 2022 |
| publisher | Springer International Publishing |
| record_format | dspace |
| spelling | mit-1721.1/1459412023-08-11T18:49:27Z Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer Bardhan, Neelkanth Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Biological Engineering Abstract In the past two decades, the emergence of nanomaterials for biomedical applications has shown tremendous promise for changing the paradigm of all aspects of disease management. Nanomaterials are particularly attractive for being a modularly tunable system; with the ability to add functionality for early diagnostics, drug delivery, therapy, treatment and monitoring of patient response. In this review, a survey of the landscape of different classes of nanomaterials being developed for applications in diagnostics and imaging, as well as for the delivery of prophylactic vaccines and therapeutics such as small molecules and biologic drugs is undertaken; with a particular focus on COVID-19 diagnostics and vaccination. Work involving bio-templated nanomaterials for high-resolution imaging applications for early cancer detection, as well as for optimal cancer treatment efficacy, is discussed. The main challenges which need to be overcome from the standpoint of effective delivery and mitigating toxicity concerns are investigated. Subsequently, a section is included with resources for researchers and practitioners in nanomedicine, to help tailor their designs and formulations from a clinical perspective. Finally, three key areas for researchers to focus on are highlighted; to accelerate the development and clinical translation of these nanomaterials, thereby unleashing the true potential of nanomedicine in healthcare. Graphical abstract 2022-10-24T12:42:14Z 2022-10-24T12:42:14Z 2022-10-17 2022-10-23T03:20:53Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/145941 Bardhan, Neelkanth. 2022. "Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer." PUBLISHER_CC en https://doi.org/10.1557/s43579-022-00257-7 Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ The Author(s) application/pdf Springer International Publishing Springer International Publishing |
| spellingShingle | Bardhan, Neelkanth Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer |
| title | Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer |
| title_full | Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer |
| title_fullStr | Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer |
| title_full_unstemmed | Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer |
| title_short | Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer |
| title_sort | nanomaterials in diagnostics imaging and delivery applications from covid 19 to cancer |
| url | https://hdl.handle.net/1721.1/145941 |
| work_keys_str_mv | AT bardhanneelkanth nanomaterialsindiagnosticsimaginganddeliveryapplicationsfromcovid19tocancer |