Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles
<jats:p>Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics. A recently developed microfabrication technique enables fabrication of a new class of injectable microparticles with a hollow core-shell structure that displ...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2022
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| Online Access: | https://hdl.handle.net/1721.1/146041 |
| _version_ | 1811089343294472192 |
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| author | Sarmadi, Morteza Ta, Christina VanLonkhuyzen, Abigail M De Fiesta, Dominique C Kanelli, Maria Sadeghi, Ilin Behrens, Adam M Ingalls, Bailey Menon, Nandita Daristotle, John L Yu, Julie Langer, Robert Jaklenec, Ana |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Sarmadi, Morteza Ta, Christina VanLonkhuyzen, Abigail M De Fiesta, Dominique C Kanelli, Maria Sadeghi, Ilin Behrens, Adam M Ingalls, Bailey Menon, Nandita Daristotle, John L Yu, Julie Langer, Robert Jaklenec, Ana |
| author_sort | Sarmadi, Morteza |
| collection | MIT |
| description | <jats:p>Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics. A recently developed microfabrication technique enables fabrication of a new class of injectable microparticles with a hollow core-shell structure that displays pulsatile release kinetics, providing such capabilities. Here, we study this technology and the resulting core-shell microstructures. We demonstrated that pulsatile release is governed by a sudden increase in porosity of the polymeric matrix, leading to the formation of a porous path connecting the core to the environment. Moreover, the release kinetics within the range studied remained primarily independent of the particle geometry but highly dependent on its composition. A qualitative technique was developed to study the pattern of pH evolution in the particles. A computational model successfully modeled deformations, indicating sudden expansion of the particle before onset of release. Results of this study contribute to the understanding and design of advanced drug delivery systems.</jats:p> |
| first_indexed | 2024-09-23T14:17:41Z |
| format | Article |
| id | mit-1721.1/146041 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:17:41Z |
| publishDate | 2022 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1460412024-03-19T14:26:30Z Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles Sarmadi, Morteza Ta, Christina VanLonkhuyzen, Abigail M De Fiesta, Dominique C Kanelli, Maria Sadeghi, Ilin Behrens, Adam M Ingalls, Bailey Menon, Nandita Daristotle, John L Yu, Julie Langer, Robert Jaklenec, Ana Massachusetts Institute of Technology. Department of Mechanical Engineering Koch Institute for Integrative Cancer Research at MIT Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Institute for Medical Engineering & Science <jats:p>Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics. A recently developed microfabrication technique enables fabrication of a new class of injectable microparticles with a hollow core-shell structure that displays pulsatile release kinetics, providing such capabilities. Here, we study this technology and the resulting core-shell microstructures. We demonstrated that pulsatile release is governed by a sudden increase in porosity of the polymeric matrix, leading to the formation of a porous path connecting the core to the environment. Moreover, the release kinetics within the range studied remained primarily independent of the particle geometry but highly dependent on its composition. A qualitative technique was developed to study the pattern of pH evolution in the particles. A computational model successfully modeled deformations, indicating sudden expansion of the particle before onset of release. Results of this study contribute to the understanding and design of advanced drug delivery systems.</jats:p> 2022-10-28T16:51:16Z 2022-10-28T16:51:16Z 2022-07-15 2022-10-28T13:55:02Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/146041 Sarmadi, Morteza, Ta, Christina, VanLonkhuyzen, Abigail M, De Fiesta, Dominique C, Kanelli, Maria et al. 2022. "Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles." Science Advances, 8 (28). en 10.1126/sciadv.abn5315 Science Advances Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Science Advances |
| spellingShingle | Sarmadi, Morteza Ta, Christina VanLonkhuyzen, Abigail M De Fiesta, Dominique C Kanelli, Maria Sadeghi, Ilin Behrens, Adam M Ingalls, Bailey Menon, Nandita Daristotle, John L Yu, Julie Langer, Robert Jaklenec, Ana Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles |
| title | Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles |
| title_full | Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles |
| title_fullStr | Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles |
| title_full_unstemmed | Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles |
| title_short | Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles |
| title_sort | experimental and computational understanding of pulsatile release mechanism from biodegradable core shell microparticles |
| url | https://hdl.handle.net/1721.1/146041 |
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