Microfluidic vascular models of tumor cell extravasation
<jats:p>Emerging microfluidic disease models have amply demonstrated their value in many fields of cancer research. These <jats:italic>in vitro</jats:italic> technologies recapitulate key aspects of metastatic cancer, including the process of tumor cell arrest and extravasation at...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Frontiers Media SA
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/1721.1/146568 |
| _version_ | 1811082096553230336 |
|---|---|
| author | Kim, Seunggyu Wan, Zhengpeng Jeon, Jessie S. Kamm, Roger D. |
| author2 | Massachusetts Institute of Technology. Mechanobiology Laboratory |
| author_facet | Massachusetts Institute of Technology. Mechanobiology Laboratory Kim, Seunggyu Wan, Zhengpeng Jeon, Jessie S. Kamm, Roger D. |
| author_sort | Kim, Seunggyu |
| collection | MIT |
| description | <jats:p>Emerging microfluidic disease models have amply demonstrated their value in many fields of cancer research. These <jats:italic>in vitro</jats:italic> technologies recapitulate key aspects of metastatic cancer, including the process of tumor cell arrest and extravasation at the site of the metastatic tumor. To date, extensive efforts have been made to capture key features of the microvasculature to reconstitute the pre-metastatic niche and investigate dynamic extravasation behaviors using microfluidic systems. In this mini-review, we highlight recent microfluidic vascular models of tumor cell extravasation and explore how this approach contributes to development of <jats:italic>in vitro</jats:italic> disease models to enhance understanding of metastasis <jats:italic>in vivo</jats:italic>.</jats:p> |
| first_indexed | 2024-09-23T11:57:30Z |
| format | Article |
| id | mit-1721.1/146568 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:57:30Z |
| publishDate | 2022 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | mit-1721.1/1465682023-02-16T16:20:06Z Microfluidic vascular models of tumor cell extravasation Kim, Seunggyu Wan, Zhengpeng Jeon, Jessie S. Kamm, Roger D. Massachusetts Institute of Technology. Mechanobiology Laboratory Massachusetts Institute of Technology. Department of Mechanical Engineering Cancer Research Oncology <jats:p>Emerging microfluidic disease models have amply demonstrated their value in many fields of cancer research. These <jats:italic>in vitro</jats:italic> technologies recapitulate key aspects of metastatic cancer, including the process of tumor cell arrest and extravasation at the site of the metastatic tumor. To date, extensive efforts have been made to capture key features of the microvasculature to reconstitute the pre-metastatic niche and investigate dynamic extravasation behaviors using microfluidic systems. In this mini-review, we highlight recent microfluidic vascular models of tumor cell extravasation and explore how this approach contributes to development of <jats:italic>in vitro</jats:italic> disease models to enhance understanding of metastasis <jats:italic>in vivo</jats:italic>.</jats:p> 2022-11-21T16:59:14Z 2022-11-21T16:59:14Z 2022-11-11 Article http://purl.org/eprint/type/JournalArticle 2234-943X https://hdl.handle.net/1721.1/146568 Kim, Seunggyu, Wan, Zhengpeng, Jeon, Jessie S. and Kamm, Roger D. 2022. "Microfluidic vascular models of tumor cell extravasation." 12. 10.3389/fonc.2022.1052192 Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Media SA Frontiers |
| spellingShingle | Cancer Research Oncology Kim, Seunggyu Wan, Zhengpeng Jeon, Jessie S. Kamm, Roger D. Microfluidic vascular models of tumor cell extravasation |
| title | Microfluidic vascular models of tumor cell extravasation |
| title_full | Microfluidic vascular models of tumor cell extravasation |
| title_fullStr | Microfluidic vascular models of tumor cell extravasation |
| title_full_unstemmed | Microfluidic vascular models of tumor cell extravasation |
| title_short | Microfluidic vascular models of tumor cell extravasation |
| title_sort | microfluidic vascular models of tumor cell extravasation |
| topic | Cancer Research Oncology |
| url | https://hdl.handle.net/1721.1/146568 |
| work_keys_str_mv | AT kimseunggyu microfluidicvascularmodelsoftumorcellextravasation AT wanzhengpeng microfluidicvascularmodelsoftumorcellextravasation AT jeonjessies microfluidicvascularmodelsoftumorcellextravasation AT kammrogerd microfluidicvascularmodelsoftumorcellextravasation |