Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells
<jats:title>Abstract</jats:title><jats:p>An intracellular antenna can open up new horizons for fundamental and applied biology. Here, we introduce the Cell Rover, a magnetostrictive antenna which can operate wirelessly inside a living cell and is compatible with 3D biological syste...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2022
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| Online Access: | https://hdl.handle.net/1721.1/146593 |
| _version_ | 1826197515262754816 |
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| author | Joy, Baju Cai, Yubin Bono, David C Sarkar, Deblina |
| author2 | Massachusetts Institute of Technology. Media Laboratory |
| author_facet | Massachusetts Institute of Technology. Media Laboratory Joy, Baju Cai, Yubin Bono, David C Sarkar, Deblina |
| author_sort | Joy, Baju |
| collection | MIT |
| description | <jats:title>Abstract</jats:title><jats:p>An intracellular antenna can open up new horizons for fundamental and applied biology. Here, we introduce the Cell Rover, a magnetostrictive antenna which can operate wirelessly inside a living cell and is compatible with 3D biological systems. It is sub-mm in size, acoustically actuated by an AC magnetic field and resonantly operated at low MHz frequencies, which is ideal for living systems. We developed an injection scheme involving non-uniform magnetic fields for intracellular injection of the Cell Rovers and demonstrated their operation in fully opaque, stage VI Xenopus oocytes, for which real-time imaging with conventional technologies is challenging. We also show that they provide a pathway for multiplexing applications to individually address multiple cells or to tune to more than one antenna within the same cell for versatile functionalities. This technology forms the foundation stone that can enable the integration of future capabilities such as smart sensing, modulation as well as energy harvesting to power in-cell nanoelectronic computing and can potentially bring the prowess of information technology inside a living cell. This could lead to unprecedented opportunities for fundamental understanding of biology as well as diagnostics and therapeutics.</jats:p> |
| first_indexed | 2024-09-23T10:48:51Z |
| format | Article |
| id | mit-1721.1/146593 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:48:51Z |
| publishDate | 2022 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1465932023-07-05T18:00:04Z Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells Joy, Baju Cai, Yubin Bono, David C Sarkar, Deblina Massachusetts Institute of Technology. Media Laboratory Massachusetts Institute of Technology. Department of Materials Science and Engineering <jats:title>Abstract</jats:title><jats:p>An intracellular antenna can open up new horizons for fundamental and applied biology. Here, we introduce the Cell Rover, a magnetostrictive antenna which can operate wirelessly inside a living cell and is compatible with 3D biological systems. It is sub-mm in size, acoustically actuated by an AC magnetic field and resonantly operated at low MHz frequencies, which is ideal for living systems. We developed an injection scheme involving non-uniform magnetic fields for intracellular injection of the Cell Rovers and demonstrated their operation in fully opaque, stage VI Xenopus oocytes, for which real-time imaging with conventional technologies is challenging. We also show that they provide a pathway for multiplexing applications to individually address multiple cells or to tune to more than one antenna within the same cell for versatile functionalities. This technology forms the foundation stone that can enable the integration of future capabilities such as smart sensing, modulation as well as energy harvesting to power in-cell nanoelectronic computing and can potentially bring the prowess of information technology inside a living cell. This could lead to unprecedented opportunities for fundamental understanding of biology as well as diagnostics and therapeutics.</jats:p> 2022-11-22T18:56:02Z 2022-11-22T18:56:02Z 2022-09-22 2022-11-22T18:49:31Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/146593 Joy, Baju, Cai, Yubin, Bono, David C and Sarkar, Deblina. 2022. "Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells." Nature Communications, 13 (1). en 10.1038/s41467-022-32862-4 Nature Communications Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Nature |
| spellingShingle | Joy, Baju Cai, Yubin Bono, David C Sarkar, Deblina Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells |
| title | Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells |
| title_full | Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells |
| title_fullStr | Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells |
| title_full_unstemmed | Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells |
| title_short | Cell Rover—a miniaturized magnetostrictive antenna for wireless operation inside living cells |
| title_sort | cell rover a miniaturized magnetostrictive antenna for wireless operation inside living cells |
| url | https://hdl.handle.net/1721.1/146593 |
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