Ago2 protects Drosophila siRNAs and microRNAs from target-directed degradation, even in the absence of 2′- O -methylation

Ago2 protects Drosophila siRNAs and microRNAs from target-directed degradation, even in the absence of 2′- O -methylation

<jats:p>Target-directed microRNA (miRNA) degradation (TDMD), which is mediated by the protein ZSWIM8, plays a widespread role in shaping miRNA abundances across bilateria. Some endogenous small interfering RNAs (siRNAs) of <jats:italic>Drosophila</jats:italic> cells have target sit...

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Bibliographic Details
Main Authors: Kingston, Elena R, Bartel, David P
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory 2022
Online Access:https://hdl.handle.net/1721.1/146763

Internet

https://hdl.handle.net/1721.1/146763

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