The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we show that αS directly modulates processing bodies (P-bodies), membraneless organelles that function in mRNA turno...

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Bibliographic Details
Main Authors: Hallacli, Erinc, Kayatekin, Can, Nazeen, Sumaiya, Wang, Xiou H, Sheinkopf, Zoe, Sathyakumar, Shubhangi, Sarkar, Souvarish, Jiang, Xin, Dong, Xianjun, Di Maio, Roberto, Wang, Wen, Keeney, Matthew T, Felsky, Daniel, Sandoe, Jackson, Vahdatshoar, Aazam, Udeshi, Namrata D, Mani, DR, Carr, Steven A, Lindquist, Susan, De Jager, Philip L, Bartel, David P, Myers, Chad L, Greenamyre, J Timothy, Feany, Mel B, Sunyaev, Shamil R, Chung, Chee Yeun, Khurana, Vikram
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/146766

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