Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia

Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia

<jats:p> Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-specific targets has significantly hampered the development of effective immune-based therapies. Recent paradigm-changing studies have shown that natural killer (NK) cells exhibit innate...

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Bibliographic Details
Main Authors: Dong, Han, Ham, James Dongjoo, Hu, Guangan, Xie, Guozhu, Vergara, Juliana, Liang, Yong, Ali, Alaa, Tarannum, Mubin, Donner, Hannah, Baginska, Joanna, Abdulhamid, Yasmin, Dinh, Khanhlinh, Soiffer, Robert J, Ritz, Jerome, Glimcher, Laurie H, Chen, Jianzhu, Romee, Rizwan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2022
Online Access:https://hdl.handle.net/1721.1/146778

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