Starting a new chapter on class Ia ribonucleotide reductases
Ribonucleotide reductases (RNRs) use radical-based chemistry to convert ribonucleotides into deoxyribonucleotides, an essential step in DNA biosynthesis and repair. There are multiple RNR classes, the best studied of which is the class Ia RNR that is found in Escherichia coli, eukaryotes including h...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2022
|
| Online Access: | https://hdl.handle.net/1721.1/146796 |
| _version_ | 1826214025646571520 |
|---|---|
| author | Levitz, Talya S Drennan, Catherine L |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Levitz, Talya S Drennan, Catherine L |
| author_sort | Levitz, Talya S |
| collection | MIT |
| description | Ribonucleotide reductases (RNRs) use radical-based chemistry to convert ribonucleotides into deoxyribonucleotides, an essential step in DNA biosynthesis and repair. There are multiple RNR classes, the best studied of which is the class Ia RNR that is found in Escherichia coli, eukaryotes including humans, and many pathogenic and nonpathogenic prokaryotes. This review covers recent advances in our understanding of class Ia RNRs, including a recent reporting of a structure of the active state of the E. coli enzyme and the impacts that the structure has had on spurring research into the mechanism of long-range radical transfer. Additionally, the review considers other recent structural and biochemical research on class Ia RNRs and the potential of that work for the development of anticancer and antibiotic therapeutics. |
| first_indexed | 2024-09-23T15:58:37Z |
| format | Article |
| id | mit-1721.1/146796 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:58:37Z |
| publishDate | 2022 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1467962022-12-08T03:03:49Z Starting a new chapter on class Ia ribonucleotide reductases Levitz, Talya S Drennan, Catherine L Massachusetts Institute of Technology. Department of Biology Ribonucleotide reductases (RNRs) use radical-based chemistry to convert ribonucleotides into deoxyribonucleotides, an essential step in DNA biosynthesis and repair. There are multiple RNR classes, the best studied of which is the class Ia RNR that is found in Escherichia coli, eukaryotes including humans, and many pathogenic and nonpathogenic prokaryotes. This review covers recent advances in our understanding of class Ia RNRs, including a recent reporting of a structure of the active state of the E. coli enzyme and the impacts that the structure has had on spurring research into the mechanism of long-range radical transfer. Additionally, the review considers other recent structural and biochemical research on class Ia RNRs and the potential of that work for the development of anticancer and antibiotic therapeutics. 2022-12-07T19:05:36Z 2022-12-07T19:05:36Z 2022-12 2022-12-07T18:59:37Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/146796 Levitz, Talya S and Drennan, Catherine L. 2022. "Starting a new chapter on class Ia ribonucleotide reductases." Current Opinion in Structural Biology, 77. en 10.1016/j.sbi.2022.102489 Current Opinion in Structural Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Levitz, Talya S Drennan, Catherine L Starting a new chapter on class Ia ribonucleotide reductases |
| title | Starting a new chapter on class Ia ribonucleotide reductases |
| title_full | Starting a new chapter on class Ia ribonucleotide reductases |
| title_fullStr | Starting a new chapter on class Ia ribonucleotide reductases |
| title_full_unstemmed | Starting a new chapter on class Ia ribonucleotide reductases |
| title_short | Starting a new chapter on class Ia ribonucleotide reductases |
| title_sort | starting a new chapter on class ia ribonucleotide reductases |
| url | https://hdl.handle.net/1721.1/146796 |
| work_keys_str_mv | AT levitztalyas startinganewchapteronclassiaribonucleotidereductases AT drennancatherinel startinganewchapteronclassiaribonucleotidereductases |