A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells
<jats:title>Abstract</jats:title><jats:p>The GATA4 transcription factor acts as a master regulator of development of multiple tissues. GATA4 also acts in a distinct capacity to control a stress-inducible pro-inflammatory secretory program that is associated with senescence, a poten...
Main Authors: | Patel, Rupesh S, Romero, Rodrigo, Watson, Emma V, Liang, Anthony C, Burger, Megan, Westcott, Peter MK, Mercer, Kim L, Bronson, Roderick T, Wooten, Eric C, Bhutkar, Arjun, Jacks, Tyler, Elledge, Stephen J |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2022
|
Online Access: | https://hdl.handle.net/1721.1/146815 |
Similar Items
-
Rapid modelling of cooperating genetic events in cancer through somatic genome editing
by: Papagiannakopoulos, Thales, et al.
Published: (2015) -
CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer
by: Ng, Sheng Rong, et al.
Published: (2020) -
Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1
by: Romero, Rodrigo, et al.
Published: (2021) -
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
by: Dayton, Talya L., et al.
Published: (2018) -
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
by: Clish, Clary B., et al.
Published: (2017)