Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we found that immunodominance is established in tumors, wherein CD8 T cell expan...

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Bibliographic Details
Main Authors: Burger, Megan L, Cruz, Amanda M, Crossland, Grace E, Gaglia, Giorgio, Ritch, Cecily C, Blatt, Sarah E, Bhutkar, Arjun, Canner, David, Kienka, Tamina, Tavana, Sara Z, Barandiaran, Alexia L, Garmilla, Andrea, Schenkel, Jason M, Hillman, Michelle, de los Rios Kobara, Izumi, Li, Amy, Jaeger, Alex M, Hwang, William L, Westcott, Peter MK, Manos, Michael P, Holovatska, Marta M, Hodi, F Stephen, Regev, Aviv, Santagata, Sandro, Jacks, Tyler
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/146816

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