The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-based strategies to combat this disease have been largely unsuccessful to date. We corroborate prior reports that a substantia...

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Bibliographic Details
Main Authors: Freed-Pastor, William A, Lambert, Laurens J, Ely, Zackery A, Pattada, Nimisha B, Bhutkar, Arjun, Eng, George, Mercer, Kim L, Garcia, Ana P, Lin, Lin, Rideout, William M, Hwang, William L, Schenkel, Jason M, Jaeger, Alex M, Bronson, Roderick T, Westcott, Peter MK, Hether, Tyler D, Divakar, Prajan, Reeves, Jason W, Deshpande, Vikram, Delorey, Toni, Phillips, Devan, Yilmaz, Omer H, Regev, Aviv, Jacks, Tyler
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2022
Online Access:https://hdl.handle.net/1721.1/146821

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