Evolution towards Virulence in a Burkholderia Two-Component System

Evolution towards Virulence in a Burkholderia Two-Component System

<jats:p> Infections caused by members of the <jats:named-content content-type="genus-species">Burkholderia cepacia</jats:named-content> complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are...

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Bibliographic Details
Main Authors: Schaefers, Matthew M, Wang, Benjamin X, Boisvert, Nicole M, Martini, Sarah J, Bonney, Sarah L, Marshall, Christopher W, Laub, Michael T, Cooper, Vaughn S, Priebe, Gregory P
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Society for Microbiology 2022
Online Access:https://hdl.handle.net/1721.1/146863
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Summary:<jats:p> Infections caused by members of the <jats:named-content content-type="genus-species">Burkholderia cepacia</jats:named-content> complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are often resistant to many antibiotics. During long-term infection of CF patients with BCC, mutations in genes encoding the FixLJ system often become prevalent, suggesting that these changes may benefit the bacteria during infection. </jats:p>

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