Evolution towards Virulence in a Burkholderia Two-Component System
<jats:p> Infections caused by members of the <jats:named-content content-type="genus-species">Burkholderia cepacia</jats:named-content> complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2022
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| Online Access: | https://hdl.handle.net/1721.1/146863 |
| _version_ | 1811070266274480128 |
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| author | Schaefers, Matthew M Wang, Benjamin X Boisvert, Nicole M Martini, Sarah J Bonney, Sarah L Marshall, Christopher W Laub, Michael T Cooper, Vaughn S Priebe, Gregory P |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Schaefers, Matthew M Wang, Benjamin X Boisvert, Nicole M Martini, Sarah J Bonney, Sarah L Marshall, Christopher W Laub, Michael T Cooper, Vaughn S Priebe, Gregory P |
| author_sort | Schaefers, Matthew M |
| collection | MIT |
| description | <jats:p>
Infections caused by members of the
<jats:named-content content-type="genus-species">Burkholderia cepacia</jats:named-content>
complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are often resistant to many antibiotics. During long-term infection of CF patients with BCC, mutations in genes encoding the FixLJ system often become prevalent, suggesting that these changes may benefit the bacteria during infection.
</jats:p> |
| first_indexed | 2024-09-23T08:33:45Z |
| format | Article |
| id | mit-1721.1/146863 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:33:45Z |
| publishDate | 2022 |
| publisher | American Society for Microbiology |
| record_format | dspace |
| spelling | mit-1721.1/1468632022-12-14T03:45:17Z Evolution towards Virulence in a Burkholderia Two-Component System Schaefers, Matthew M Wang, Benjamin X Boisvert, Nicole M Martini, Sarah J Bonney, Sarah L Marshall, Christopher W Laub, Michael T Cooper, Vaughn S Priebe, Gregory P Massachusetts Institute of Technology. Department of Biology <jats:p> Infections caused by members of the <jats:named-content content-type="genus-species">Burkholderia cepacia</jats:named-content> complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are often resistant to many antibiotics. During long-term infection of CF patients with BCC, mutations in genes encoding the FixLJ system often become prevalent, suggesting that these changes may benefit the bacteria during infection. </jats:p> 2022-12-13T18:34:47Z 2022-12-13T18:34:47Z 2021 2022-12-13T18:23:39Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/146863 Schaefers, Matthew M, Wang, Benjamin X, Boisvert, Nicole M, Martini, Sarah J, Bonney, Sarah L et al. 2021. "Evolution towards Virulence in a Burkholderia Two-Component System." mBio, 12 (4). en 10.1128/MBIO.01823-21 mBio Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf American Society for Microbiology American Society for Microbiology |
| spellingShingle | Schaefers, Matthew M Wang, Benjamin X Boisvert, Nicole M Martini, Sarah J Bonney, Sarah L Marshall, Christopher W Laub, Michael T Cooper, Vaughn S Priebe, Gregory P Evolution towards Virulence in a Burkholderia Two-Component System |
| title | Evolution towards Virulence in a Burkholderia Two-Component System |
| title_full | Evolution towards Virulence in a Burkholderia Two-Component System |
| title_fullStr | Evolution towards Virulence in a Burkholderia Two-Component System |
| title_full_unstemmed | Evolution towards Virulence in a Burkholderia Two-Component System |
| title_short | Evolution towards Virulence in a Burkholderia Two-Component System |
| title_sort | evolution towards virulence in a burkholderia two component system |
| url | https://hdl.handle.net/1721.1/146863 |
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