A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP

A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP

<jats:p> Drug-resistant Gram-negative bacteria have become the major problem driving the antimicrobial resistance crisis. Searching outside the overmined actinomycetes, we focused on <jats:italic>Photorhabdus</jats:italic> , gut symbionts of e...

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Bibliographic Details
Main Authors: Shahsavari, Negar, Wang, Boyuan, Imai, Yu, Mori, Miho, Son, Sangkeun, Liang, Libang, Böhringer, Nils, Manuse, Sylvie, Gates, Michael F, Morrissette, Madeleine, Corsetti, Rachel, Espinoza, Josh L, Dupont, Chris L, Laub, Michael T, Lewis, Kim
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Society for Microbiology 2022
Online Access:https://hdl.handle.net/1721.1/146865
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Summary:<jats:p> Drug-resistant Gram-negative bacteria have become the major problem driving the antimicrobial resistance crisis. Searching outside the overmined actinomycetes, we focused on <jats:italic>Photorhabdus</jats:italic> , gut symbionts of enthomopathogenic nematodes that carry up to 40 biosynthetic gene clusters coding for secondary metabolites. </jats:p>

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