MITF deficiency accelerates GNAQ-driven uveal melanoma
<jats:title>Significance</jats:title> <jats:p> Uveal melanoma (UM) is a cancer of eye melanocytes. Although relatively rare, UM is extremely deadly, as approximately half of all patients develop liver metastases for which there are no approved therapies. Eve...
| প্রধান লেখক: | , , , |
|---|---|
| অন্যান্য লেখক: | |
| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Proceedings of the National Academy of Sciences
2022
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| অনলাইন ব্যবহার করুন: | https://hdl.handle.net/1721.1/146880 |
| _version_ | 1826214124172869632 |
|---|---|
| author | Phelps, Grace B Hagen, Hannah R Amsterdam, Adam Lees, Jacqueline A |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Phelps, Grace B Hagen, Hannah R Amsterdam, Adam Lees, Jacqueline A |
| author_sort | Phelps, Grace B |
| collection | MIT |
| description | <jats:title>Significance</jats:title>
<jats:p>
Uveal melanoma (UM) is a cancer of eye melanocytes. Although relatively rare, UM is extremely deadly, as approximately half of all patients develop liver metastases for which there are no approved therapies. Even therapies that succeed in cutaneous melanoma (CM) treatment have proven ineffectual for UM, highlighting both the distinct nature of these two melanomas and the need to understand the differences between them. Here, we show that autochthonous UM tumors are rapidly induced by activated YAP and can lack hyperactive ERK, highlighting YAP as a promising therapeutic target. We further show that
<jats:italic>MITF</jats:italic>
functions as a tumor suppressor in UM in contrast to its essential role in CM, establishing that MITF inhibition should not be entertained for UM treatment.
</jats:p> |
| first_indexed | 2024-09-23T16:00:12Z |
| format | Article |
| id | mit-1721.1/146880 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:00:12Z |
| publishDate | 2022 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1468802022-12-15T03:04:13Z MITF deficiency accelerates GNAQ-driven uveal melanoma Phelps, Grace B Hagen, Hannah R Amsterdam, Adam Lees, Jacqueline A Massachusetts Institute of Technology. Department of Biology <jats:title>Significance</jats:title> <jats:p> Uveal melanoma (UM) is a cancer of eye melanocytes. Although relatively rare, UM is extremely deadly, as approximately half of all patients develop liver metastases for which there are no approved therapies. Even therapies that succeed in cutaneous melanoma (CM) treatment have proven ineffectual for UM, highlighting both the distinct nature of these two melanomas and the need to understand the differences between them. Here, we show that autochthonous UM tumors are rapidly induced by activated YAP and can lack hyperactive ERK, highlighting YAP as a promising therapeutic target. We further show that <jats:italic>MITF</jats:italic> functions as a tumor suppressor in UM in contrast to its essential role in CM, establishing that MITF inhibition should not be entertained for UM treatment. </jats:p> 2022-12-14T18:00:31Z 2022-12-14T18:00:31Z 2022 2022-12-14T17:54:03Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/146880 Phelps, Grace B, Hagen, Hannah R, Amsterdam, Adam and Lees, Jacqueline A. 2022. "MITF deficiency accelerates GNAQ-driven uveal melanoma." Proceedings of the National Academy of Sciences of the United States of America, 119 (19). en 10.1073/PNAS.2107006119 Proceedings of the National Academy of Sciences of the United States of America Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Phelps, Grace B Hagen, Hannah R Amsterdam, Adam Lees, Jacqueline A MITF deficiency accelerates GNAQ-driven uveal melanoma |
| title | MITF deficiency accelerates GNAQ-driven uveal melanoma |
| title_full | MITF deficiency accelerates GNAQ-driven uveal melanoma |
| title_fullStr | MITF deficiency accelerates GNAQ-driven uveal melanoma |
| title_full_unstemmed | MITF deficiency accelerates GNAQ-driven uveal melanoma |
| title_short | MITF deficiency accelerates GNAQ-driven uveal melanoma |
| title_sort | mitf deficiency accelerates gnaq driven uveal melanoma |
| url | https://hdl.handle.net/1721.1/146880 |
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