Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

Weighing the DNA Content of Adeno-Associated Virus Vectors with Zeptogram Precision Using Nanomechanical Resonators

Quantifying the composition of viral vectors used in vaccine development and gene therapy is critical for assessing their functionality. Adeno-associated virus (AAV) vectors, which are the most widely used viral vectors for in vivo gene therapy, are typically characterized using PCR, ELISA, and anal...

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Bibliographic Details
Main Authors: Katsikis, Georgios, Hwang, Iris E, Wang, Wade, Bhat, Vikas S, McIntosh, Nicole L, Karim, Omair A, Blus, Bartlomiej J, Sha, Sha, Agache, Vincent, Wolfrum, Jacqueline M, Springs, Stacy L, Sinskey, Anthony J, Barone, Paul W, Braatz, Richard D, Manalis, Scott R
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Chemical Society (ACS) 2023
Online Access:https://hdl.handle.net/1721.1/146983

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