Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

<jats:p>Effective antitumor immunity in mice requires activation of the type I interferon (IFN) response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer from limited efficacy and high toxicity. Intratumoral IFN retention ameliorates systemic toxicity, but given the...

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Bibliographic Details
Main Authors: Lutz, Emi A, Agarwal, Yash, Momin, Noor, Cowles, Sarah C, Palmeri, Joseph R, Duong, Ellen, Hornet, Vladlena, Sheen, Allison, Lax, Brianna M, Rothschilds, Adrienne M, Irvine, Darrell J, Spranger, Stefani, Wittrup, K Dane
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2023
Online Access:https://hdl.handle.net/1721.1/146987

Internet

https://hdl.handle.net/1721.1/146987

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