Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies

<jats:p>Effective antitumor immunity in mice requires activation of the type I interferon (IFN) response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer from limited efficacy and high toxicity. Intratumoral IFN retention ameliorates systemic toxicity, but given the...

书目详细资料
Main Authors:	Lutz, Emi A, Agarwal, Yash, Momin, Noor, Cowles, Sarah C, Palmeri, Joseph R, Duong, Ellen, Hornet, Vladlena, Sheen, Allison, Lax, Brianna M, Rothschilds, Adrienne M, Irvine, Darrell J, Spranger, Stefani, Wittrup, K Dane
其他作者:	Koch Institute for Integrative Cancer Research at MIT
格式:	文件
语言:	English
出版:	Proceedings of the National Academy of Sciences 2023
在线阅读:	https://hdl.handle.net/1721.1/146987

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