Structural advances in transcription elongation
Transcription is the first step of gene expression and involves RNA polymerases. After transcription initiation, RNA polymerase enters elongation followed by transcription termination at the end of the gene. Only recently, structures of transcription elongation complexes bound to key transcription e...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2023
|
| Online Access: | https://hdl.handle.net/1721.1/147010 |
| _version_ | 1826195866302545920 |
|---|---|
| author | Mohamed, Abdallah A Vazquez Nunez, Roberto Vos, Seychelle M |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Mohamed, Abdallah A Vazquez Nunez, Roberto Vos, Seychelle M |
| author_sort | Mohamed, Abdallah A |
| collection | MIT |
| description | Transcription is the first step of gene expression and involves RNA polymerases. After transcription initiation, RNA polymerase enters elongation followed by transcription termination at the end of the gene. Only recently, structures of transcription elongation complexes bound to key transcription elongation factors have been determined in bacterial and eukaryotic systems. These structures have revealed numerous insights including the basis for transcriptional pausing, RNA polymerase interaction with large complexes such as the ribosome and the spliceosome, and the transition into productive elongation. Here, we review these structures and describe areas for future research. |
| first_indexed | 2024-09-23T10:16:47Z |
| format | Article |
| id | mit-1721.1/147010 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:16:47Z |
| publishDate | 2023 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1470102023-08-15T04:39:23Z Structural advances in transcription elongation Mohamed, Abdallah A Vazquez Nunez, Roberto Vos, Seychelle M Massachusetts Institute of Technology. Department of Biology Transcription is the first step of gene expression and involves RNA polymerases. After transcription initiation, RNA polymerase enters elongation followed by transcription termination at the end of the gene. Only recently, structures of transcription elongation complexes bound to key transcription elongation factors have been determined in bacterial and eukaryotic systems. These structures have revealed numerous insights including the basis for transcriptional pausing, RNA polymerase interaction with large complexes such as the ribosome and the spliceosome, and the transition into productive elongation. Here, we review these structures and describe areas for future research. 2023-01-09T16:03:31Z 2023-01-09T16:03:31Z 2022-08 2023-01-09T15:59:06Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147010 Mohamed, Abdallah A, Vazquez Nunez, Roberto and Vos, Seychelle M. 2022. "Structural advances in transcription elongation." Current Opinion in Structural Biology, 75. en 10.1016/j.sbi.2022.102422 Current Opinion in Structural Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Mohamed, Abdallah A Vazquez Nunez, Roberto Vos, Seychelle M Structural advances in transcription elongation |
| title | Structural advances in transcription elongation |
| title_full | Structural advances in transcription elongation |
| title_fullStr | Structural advances in transcription elongation |
| title_full_unstemmed | Structural advances in transcription elongation |
| title_short | Structural advances in transcription elongation |
| title_sort | structural advances in transcription elongation |
| url | https://hdl.handle.net/1721.1/147010 |
| work_keys_str_mv | AT mohamedabdallaha structuraladvancesintranscriptionelongation AT vazqueznunezroberto structuraladvancesintranscriptionelongation AT vosseychellem structuraladvancesintranscriptionelongation |