Biomolecular Condensates in the Nucleus
© 2020 Elsevier Ltd Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their way to specific locations has been assumed to occur largely by diffusion...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2023
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| Online Access: | https://hdl.handle.net/1721.1/147013 |
| _version_ | 1826189932525256704 |
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| author | Sabari, Benjamin R Dall’Agnese, Alessandra Young, Richard A |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sabari, Benjamin R Dall’Agnese, Alessandra Young, Richard A |
| author_sort | Sabari, Benjamin R |
| collection | MIT |
| description | © 2020 Elsevier Ltd Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their way to specific locations has been assumed to occur largely by diffusion-mediated collisions. Recent studies have shown that many nuclear processes occur within condensates that compartmentalize and concentrate the protein and RNA molecules required for each process, typically at specific genomic loci. These condensates have common features and emergent properties that provide the cell with regulatory capabilities beyond canonical molecular regulatory mechanisms. We describe here the shared features of nuclear condensates, the components that produce locus-specific condensates, elements of specificity, and the emerging understanding of mechanisms regulating these compartments. |
| first_indexed | 2024-09-23T08:31:57Z |
| format | Article |
| id | mit-1721.1/147013 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:31:57Z |
| publishDate | 2023 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1470132023-01-10T03:47:34Z Biomolecular Condensates in the Nucleus Sabari, Benjamin R Dall’Agnese, Alessandra Young, Richard A Massachusetts Institute of Technology. Department of Biology © 2020 Elsevier Ltd Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their way to specific locations has been assumed to occur largely by diffusion-mediated collisions. Recent studies have shown that many nuclear processes occur within condensates that compartmentalize and concentrate the protein and RNA molecules required for each process, typically at specific genomic loci. These condensates have common features and emergent properties that provide the cell with regulatory capabilities beyond canonical molecular regulatory mechanisms. We describe here the shared features of nuclear condensates, the components that produce locus-specific condensates, elements of specificity, and the emerging understanding of mechanisms regulating these compartments. 2023-01-09T16:48:13Z 2023-01-09T16:48:13Z 2020 2023-01-09T16:44:55Z Article http://purl.org/eprint/type/JournalArticle https://hdl.handle.net/1721.1/147013 Sabari, Benjamin R, Dall’Agnese, Alessandra and Young, Richard A. 2020. "Biomolecular Condensates in the Nucleus." Trends in Biochemical Sciences, 45 (11). en 10.1016/J.TIBS.2020.06.007 Trends in Biochemical Sciences Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Sabari, Benjamin R Dall’Agnese, Alessandra Young, Richard A Biomolecular Condensates in the Nucleus |
| title | Biomolecular Condensates in the Nucleus |
| title_full | Biomolecular Condensates in the Nucleus |
| title_fullStr | Biomolecular Condensates in the Nucleus |
| title_full_unstemmed | Biomolecular Condensates in the Nucleus |
| title_short | Biomolecular Condensates in the Nucleus |
| title_sort | biomolecular condensates in the nucleus |
| url | https://hdl.handle.net/1721.1/147013 |
| work_keys_str_mv | AT sabaribenjaminr biomolecularcondensatesinthenucleus AT dallagnesealessandra biomolecularcondensatesinthenucleus AT youngricharda biomolecularcondensatesinthenucleus |