Targeting transcription in heart failure via CDK7/12/13 inhibition

Targeting transcription in heart failure via CDK7/12/13 inhibition

<jats:title>Abstract</jats:title><jats:p>Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality, highlighting an urgent need for new therapeutic strategies. As stress-activated cardiac signaling cascades converge on the nucleus to drive maladaptive g...

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Bibliographic Details
Main Authors: Hsu, Austin, Duan, Qiming, Day, Daniel S, Luo, Xin, McMahon, Sarah, Huang, Yu, Feldman, Zachary B, Jiang, Zhen, Zhang, Tinghu, Liang, Yanke, Alexanian, Michael, Padmanabhan, Arun, Brown, Jonathan D, Lin, Charles Y, Gray, Nathanael S, Young, Richard A, Bruneau, Benoit G, Haldar, Saptarsi M
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/147016

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