Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

<jats:title>Abstract</jats:title> <jats:p>Altered metabolism helps sustain cancer cell proliferation and survival. Most cancers, including prostate cancers, express the M2 splice isoform of pyruvate kinase (PKM2), which can support anabolic metabolism to support cel...

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Bibliographic Details
Main Authors: Davidson, Shawn M, Schmidt, Daniel R, Heyman, Julia E, O'Brien, James P, Liu, Amy C, Israelsen, William J, Dayton, Talya L, Sehgal, Raghav, Bronson, Roderick T, Freinkman, Elizaveta, Mak, Howard H, Fanelli, Giuseppe Nicolò, Malstrom, Scott, Bellinger, Gary, Carracedo, Arkaitz, Pandolfi, Pier Paolo, Courtney, Kevin D, Jha, Abhishek, DePinho, Ronald A, Horner, James W, Thomas, Craig J, Cantley, Lewis C, Loda, Massimo, Vander Heiden, Matthew G
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: American Association for Cancer Research (AACR) 2023
Online Access:https://hdl.handle.net/1721.1/147020

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